Exosomes and Nanoengineering: A Match Made for Precision Therapeutics.,Advanced Materials

当前位置： X-MOL 学术 › Adv. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Exosomes and Nanoengineering: A Match Made for Precision Therapeutics.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-09-18 , DOI: 10.1002/adma.201904040
Phuong H L Tran ₁ , Dongxi Xiang ₂ , Thao T D Tran _{3,

4} , Wang Yin ₁ , Yumei Zhang ₁ , Lingxue Kong ₅ , Kuisheng Chen ₆ , Miaomiao Sun ₆ , Yong Li ₇ , Yingchun Hou ₈ , Yimin Zhu ₉ , Wei Duan _{1,

10,

11}

Affiliation

School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, 3216, Australia.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, 77 Avenue Louise Pasteur, Boston, MA, 02115, USA.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Institute for Frontier Materials, Deakin University, Geelong, Victoria, 3216, Australia.
Department of Pathology, The First Affiliated Hospital, Zhengzhou University, He'nan Key Laboratory of Tumor Pathology, Zhengzhou, 450052, China.
Cancer Care Centre, St George Hospital, Kogarah, and St George and Sutherland Clinical School, University of New South Wales, Kensington, NSW, 2217, Australia.
Laboratory of Tumor Molecular and Cellular Biology, College of Life Sciences, Shaanxi Normal University, 620 West Chang'an Avenue, Xi'an, Shaanxi, 710119, China.
CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.
GenePharma-Deakin Joint Laboratory of Aptamer Medicine, Suzhou, 215123, China.
GenePharma-Deakin Joint Laboratory of Aptamer Medicine, Waurn Ponds, Victoria, 3216, Australia.

Targeted exosomal delivery systems for precision nanomedicine attract wide interest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering. Exosomes are naturally derived 50-150 nm nanovesicles that play important roles in cell-to-cell and/or cell-to-tissue communications and cross-species communication. Exosomes are also a promising class of novel drug delivery vehicles owing to their ability to shield their payload from chemical and enzymatic degradations as well as to evade recognition by and subsequent removal by the immune system. Combined with a new class of affinity ligands known as aptamers or chemical antibodies, molecularly targeted exosomes are poised to become the next generation of smartly engineered nanovesicles for precision medicine. Here, recent advances in targeted exosomal delivery systems engineered by aptamer for future strategies to promote human health using this class of human-derived nanovesicles are summarized.

中文翻译：

外泌体和纳米工程：精确治疗的匹配。

精准纳米医学的靶向外泌体递送系统引起了分子细胞生物学，药物科学和纳米工程领域的广泛兴趣。外泌体是天然来源的50-150 nm纳米囊泡，在细胞与细胞和/或细胞与组织的交流以及跨物种的交流中起重要作用。外来体由于其能够保护其有效载荷免受化学和酶促降解以及逃避免疫系统的识别以及随后被免疫系统清除的能力，因此也是一类有希望的新型药物递送载体。与一类称为适体或化学抗体的新型亲和配体相结合，分子靶向的外泌体有望成为下一代精巧设计的精密医学纳米囊泡。这里，

更新日期：2019-09-18

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南