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Improving Covalent Organic Frameworks Fluorescence by Triethylamine Pinpoint Surgery as Selective Biomarker Sensor for Diabetes Mellitus Diagnosis
Analytical Chemistry ( IF 6.7 ) Pub Date : 2019-09-24 00:00:00 , DOI: 10.1021/acs.analchem.9b03534 Jinmin Wang 1 , Bing Yan 1, 2
Analytical Chemistry ( IF 6.7 ) Pub Date : 2019-09-24 00:00:00 , DOI: 10.1021/acs.analchem.9b03534 Jinmin Wang 1 , Bing Yan 1, 2
Affiliation
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The nitrogen-containing imine or hydrazone linked covalent organic frameworks (COFs) are poorly luminescent due to the fluorescence quenching by nitrogen atoms in the linkages, even if highly luminescent units and linkers are employed. The fluorescence quenching pathway to prevent linkage-originated to mitigate the inherent limitations of the linkage is a promising method for luminescent COFs. The generation of N– by deprotonation of the N–H unit eliminates the electron transfer from N lone pair to COF (TpPa-1) and enhances the luminescence. In this work, TpPa-1 achieved turn-on luminescence response with good sensitivity and reproducibility toward triethylamine (TEA) vapor in the process of deprotonation. The fabricated detector offers a viable approach for sensing ppm-level TEA, which can remind people to take timely measures to reduce the environmental hazards caused by TEA. The fluorescent sensor TpPa-1@LE constructed by the products of TpPa-1 and TEA can quantitatively trace biomarker methylglyoxal (MGO) for diabetes mellitus diagnosis in serum system. Furthermore, using TEA and MGO as input signals and the two fluorescence emissions G476 and Y525 as output signals, an advanced analytical device based on two Boolean logic gates with INH and AND function is constructed. This work provides a new strategy for improving the weak luminescence of COF in aqueous solution and realizes selective response to biomarker (MGO) for diabetes mellitus diagnosis.
中文翻译：
通过三乙胺精确手术改善共价有机框架的荧光作为糖尿病诊断的选择性生物标志物传感器。
即使使用高度发光的单元和接头，含氮的亚胺或CO连接的共价有机骨架（COF）的发光也会由于连接中氮原子的荧光猝灭而导致发光不良。防止猝灭源于连锁以减轻连锁固有局限性的荧光猝灭途径是发光COF的有前途的方法。通过N–H单元去质子化生成N –消除了电子从N个孤对向COF（TpPa-1）的转移，并增强了发光。在这项工作中，TpPa-1在去质子化过程中实现了对三乙胺（TEA）蒸气具有良好灵敏度和重现性的开启发光响应。预制的探测器提供了一种检测ppm级TEA的可行方法，该方法可以提醒人们及时采取措施以减少由TEA引起的环境危害。荧光传感器TPPA-1 @ LE构造通过的产物TPPA-1TEA可以定量追踪生物标志物甲基乙二醛（MGO），用于血清系统中的糖尿病诊断。此外，以TEA和MGO作为输入信号，并以两个荧光发射G476和Y525作为输出信号，构建了一个基于两个具有INH和AND功能的布尔逻辑门的高级分析设备。这项工作为改善水溶液中COF的弱发光提供了新的策略，并实现了对生物标志物（MGO）的选择性反应，可用于糖尿病的诊断。
更新日期：2019-09-25
中文翻译：
通过三乙胺精确手术改善共价有机框架的荧光作为糖尿病诊断的选择性生物标志物传感器。
即使使用高度发光的单元和接头，含氮的亚胺或CO连接的共价有机骨架（COF）的发光也会由于连接中氮原子的荧光猝灭而导致发光不良。防止猝灭源于连锁以减轻连锁固有局限性的荧光猝灭途径是发光COF的有前途的方法。通过N–H单元去质子化生成N –消除了电子从N个孤对向COF（TpPa-1）的转移，并增强了发光。在这项工作中，TpPa-1在去质子化过程中实现了对三乙胺（TEA）蒸气具有良好灵敏度和重现性的开启发光响应。预制的探测器提供了一种检测ppm级TEA的可行方法，该方法可以提醒人们及时采取措施以减少由TEA引起的环境危害。荧光传感器TPPA-1 @ LE构造通过的产物TPPA-1TEA可以定量追踪生物标志物甲基乙二醛（MGO），用于血清系统中的糖尿病诊断。此外，以TEA和MGO作为输入信号，并以两个荧光发射G476和Y525作为输出信号，构建了一个基于两个具有INH和AND功能的布尔逻辑门的高级分析设备。这项工作为改善水溶液中COF的弱发光提供了新的策略，并实现了对生物标志物（MGO）的选择性反应，可用于糖尿病的诊断。
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