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Biodegradable iron-coordinated hollow polydopamine nanospheres for dihydroartemisinin delivery and selectively enhanced therapy in tumor cells.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-10-16 , DOI: 10.1039/c9tb01397k Liang Dong 1 , Chao Wang , Wenyao Zhen , Xiaodan Jia , Shangjie An , Zhiai Xu , Wen Zhang , Xiue Jiang
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-10-16 , DOI: 10.1039/c9tb01397k Liang Dong 1 , Chao Wang , Wenyao Zhen , Xiaodan Jia , Shangjie An , Zhiai Xu , Wen Zhang , Xiue Jiang
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As the semisynthetic derivative and active metabolite of the effective anti-malarial drug artemisinin, dihydroartemisinin (DHA) has been investigated as an emerging therapeutic agent for tumor treatment based on the cytotoxicity of free-radicals originating from interactions with ferrous ions. Meanwhile, simultaneously delivering DHA and iron ions to tumors for selectively killing cancer cells is still a great challenge in DHA tumor therapy. Herein, we develop a facile yet efficient strategy based on iron-coordinated hollow polydopamine nanospheres to load DHA (DHA@HPDA-Fe). The as-prepared nanoagent is biodegradable and exhibits controllable release of DHA and Fe ions in tumor microenvironments, resulting in ferrous ion-enhanced production of cytotoxic reactive oxygen species (ROS) by DHA and thus effectively killing the tumor cells. In vivo therapy experiments indicated that the anti-tumor efficacy of DHA@HPDA-Fe was about 3.05 times greater than that of free DHA, and the tumor inhibition ratio was 88.7% compared with the control group, accompanied by negligible side effects, indicating that the proposed nanomedicine platform is promising for anti-tumor applications.
中文翻译：
可生物降解的铁配位中空聚多巴胺纳米球用于双氢青蒿素递送和选择性增强肿瘤细胞治疗。
作为有效抗疟疾药物青蒿素的半合成衍生物和活性代谢物，双氢青蒿素 (DHA) 已被研究作为一种新兴的肿瘤治疗剂，其基于与亚铁离子相互作用产生的自由基的细胞毒性。同时，将DHA和铁离子同时递送至肿瘤以选择性杀伤癌细胞仍然是DHA肿瘤治疗的一大挑战。在此，我们开发了一种基于铁配位的空心聚多巴胺纳米球来加载 DHA（DHA@HPDA-Fe）的简单而有效的策略。所制备的纳米剂是可生物降解的，并且在肿瘤微环境中表现出可控的 DHA 和 Fe 离子释放，导致亚铁离子增强 DHA 产生细胞毒性活性氧 (ROS)，从而有效地杀死肿瘤细胞。
更新日期：2019-10-17
中文翻译：
可生物降解的铁配位中空聚多巴胺纳米球用于双氢青蒿素递送和选择性增强肿瘤细胞治疗。
作为有效抗疟疾药物青蒿素的半合成衍生物和活性代谢物，双氢青蒿素 (DHA) 已被研究作为一种新兴的肿瘤治疗剂，其基于与亚铁离子相互作用产生的自由基的细胞毒性。同时，将DHA和铁离子同时递送至肿瘤以选择性杀伤癌细胞仍然是DHA肿瘤治疗的一大挑战。在此，我们开发了一种基于铁配位的空心聚多巴胺纳米球来加载 DHA（DHA@HPDA-Fe）的简单而有效的策略。所制备的纳米剂是可生物降解的，并且在肿瘤微环境中表现出可控的 DHA 和 Fe 离子释放，导致亚铁离子增强 DHA 产生细胞毒性活性氧 (ROS)，从而有效地杀死肿瘤细胞。
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