When encephalitogenic T cells collaborate with microglia in multiple sclerosis.,Nature Reviews Neurology

当前位置： X-MOL 学术 › Nat. Rev. Neurol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

When encephalitogenic T cells collaborate with microglia in multiple sclerosis.
Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2019-09-16 , DOI: 10.1038/s41582-019-0253-6
Yifei Dong ₁ , V Wee Yong ₁

Affiliation

Immune cells mediate critical inflammatory and neurodegenerative processes in the CNS in individuals with multiple sclerosis (MS). In MS, activated microglia, border-associated macrophages and monocyte-derived macrophages in the CNS can encounter T cells that have infiltrated the brain parenchyma from the circulation. Although microglia and T cells both contribute to normal CNS development and homeostasis, evidence suggests that the meeting of activated microglia and macrophages with encephalitogenic T cells exacerbates their capacity to inflict injury. This crosstalk involves many cell-surface molecules, cytokines and neurotoxic factors. In this Review, we summarize the mechanisms and consequences of T cell-microglia interactions as identified with in vitro experiments and animal models, and discuss the challenges that arise when translating this preclinical knowledge to MS in humans. We also consider therapeutic approaches to MS of which the mechanisms involve prevention or modulation of T cell and microglia responses and their interactions.

中文翻译：

当脑炎性 T 细胞与多发性硬化症中的小胶质细胞协作时。

免疫细胞介导多发性硬化症 (MS) 个体中枢神经系统中的关键炎症和神经退行性过程。在 MS 中，CNS 中活化的小胶质细胞、边界相关巨噬细胞和单核细胞衍生的巨噬细胞可以遇到从循环中渗入脑实质的 T 细胞。尽管小胶质细胞和 T 细胞都有助于正常的中枢神经系统发育和稳态，但有证据表明，活化的小胶质细胞和巨噬细胞与致脑炎性 T 细胞的相遇会加剧它们造成伤害的能力。这种串扰涉及许多细胞表面分子、细胞因子和神经毒性因子。在这篇综述中，我们总结了体外实验和动物模型确定的 T 细胞-小胶质细胞相互作用的机制和后果，并讨论将这些临床前知识转化为人类 MS 时出现的挑战。我们还考虑了 MS 的治疗方法，其机制涉及预防或调节 T 细胞和小胶质细胞反应及其相互作用。

更新日期：2019-09-16

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南