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A multifunctional quinoxalin-based AIEgen used for fluorescent thermo-sensing and image-guided photodynamic therapy
Sensors and Actuators B: Chemical ( IF 8.0 ) Pub Date : 2019-09-13 , DOI: 10.1016/j.snb.2019.127139
Yuanyuan Li , Qiuchen Peng , Shijun Li , Yuchen Cai , Bin Zhang , Kai Sun , Junbao Ma , Cuiping Yang , Hongwei Hou , Huifang Su , Kai Li

Luminogens with aggregation-induced emission (AIE) characteristic drew extraordinary attention owing to their excellent luminescence properties in aggregated state or solid state, which showed wide application prospect in chemical sensing, bioimaging, lighting material and display material. In this work, a novel AIE molecule of (2,3-bis(4-(dimethylamino)phenyl)quinoxalin-6-yl)(phenyl)methanone (designated as LD-red) was facilely synthesized through a single-step reaction with commercially available materials. Based on its intrinsic twisted intramolecular charge transfer (TICT) characteristic, LD-red was successfully utilized as a reversible fluorescent thermometer. More importantly, LD-red exhibited good biocompatibility, which not only can be used as a probe for lipid droplets-specific imaging, but also can work as a promising photosensitizer to kill cancer cells through generation of reactive oxygen species (ROS) upon white light irradiation. LD-red enriches the kinds of AIEgens and, more importantly, this work provides a new strategy for constructing multifunctional AIEgen with TICT characteristic.



中文翻译:

多功能基于喹喔啉的AIEgen用于荧光热敏和图像引导的光动力疗法

具有聚集诱导发射(AIE)特性的发光剂因其在聚集态或固态下的优异发光性能而备受关注,在化学传感,生物成像,照明材料和显示材料中显示出广阔的应用前景。在这项工作中,一种新型的(2,3-双(4-(二甲基氨基)苯基)喹喔啉-6-基)(苯基)甲酮(称为LD-red)的AIE分子通过与市售材料。基于其固有的扭曲分子内电荷转移(TICT)特性,LD-红色已成功地用作可逆荧光温度计。更重要的是LD-red具有良好的生物相容性,不仅可以用作脂质液滴特异性成像的探针,而且还可以用作有前途的光敏剂,通过在白光照射下产生活性氧(ROS)杀死癌细胞。LD-red丰富了AIEgen的种类,更重要的是,这项工作为构建具有TICT特性的多功能AIEgen提供了新的策略。

更新日期:2019-09-13
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