Two heterobimetallic μ-dppm bridged Fe,Ru complexes, [(η⁶-Arene)RuCl₂(μ-dppm)Fe(CO)I(η⁵-C₅H₅)] (Ar = C₆H₆ (1) and p-cymene (2), dppm = 1,1-bis(diphenylphosphino)methane) were obtained in a facile reaction between [Fe(η⁵-C₅H₅)I(CO)(κ¹-dppm)] (5) and the corresponding [(η⁶-Arene)RuCl₂]₂ complexes by dimer cleavage, mediated by the pendant -PPh₂ in 5. The homodinuclear Ru,Ru complex, [(η⁶-C₆H₆)RuCl₂(μ-dppm)RuCl₂(η⁶-C₆H₆)] (3), was also isolated in a straightforward fashion upon reaction of [(η⁶-C₆H₆)RuCl₂(κ¹-dppm)] (4) with [(η⁶-C₆H₆)RuCl₂]₂. All complexes were fully characterized by multinuclear (¹H, ¹³C{¹H}, ³¹P{¹H}) NMR, UV–Vis, IR spectroscopy and HRMS (ESI), and additionally complex 3 was characterized by single crystal X-ray diffraction. Density functional theory (DFT) calculations (Level of theory B3LYP, basis set for H, C, P, O, N and Cl is 6-31 + G(d,p) and for Ru,Fe DGDZVP) of 1, 2 and 3 are also reported. Complexes 1 and 2 feature HOMOs and LUMOs delocalized over the iron-centered terminus of the bimetallic complexes. The cytotoxicity of 1–5 were evaluated on A2780 and A2780cisR (Human ovarian carcinoma) cell lines and the HEK293 (Human embryonic kidney) cell line. The complexes containing iron are more cytotoxic than cisplatin in the A2780 cells and significantly more active in the A2780cisR cell line and exhibit some selectivity towards the cancer cells. The dinuclear Ru,Ru complex 3 and the mononuclear complex 4 exhibit moderate activity on A2780 and A2780cisR cells also with some cancer cell selectivity. This study hence reveals the potential of Fe,Ru complexes as potent cytotoxic agents.

两个的异μ-DPPM桥接的Fe，Ru配合物，[（η ⁶ -Arene）的RuCl ₂（μ-DPPM）的Fe（CO）I（η ⁵ -C ₅ H ^ ₅）]（AR = C ₆ H ^ ₆（1）和p -cymene（2），DPPM =在之间的容易的反应，得到1,1-双（二苯基膦基）甲烷）的[Fe（η ⁵ -C ₅ H ^ ₅）I（CO）（κ ¹ -dppm）]（5）和相应的[（η ⁶ -Arene）的RuCl ₂ ] _2个络合物由二聚物裂解，通过悬介导-PPh ₂在5。的同双核钌，钌络合物，[（η ⁶ -C ₆ H ^ ₆）的RuCl ₂（μ-DPPM）的RuCl ₂（η ⁶ -C ₆ H ^ ₆）]（3），也以直接的方式时的反应中分离[（η ⁶ -C ₆ H ^ ₆）的RuCl ₂（κ ¹ -dppm）]（4）与[（η ⁶ -C ₆ H ^ ₆）的RuCl ₂ ] ₂。所有复合物均具有多核（¹ H，¹³ C {¹ H}，³¹ P { ¹ H}）NMR，UV-Vis，IR光谱和HRMS（ESI）以及另外的配合物3用单晶X射线衍射表征。密度泛函理论（DFT）计算（等级理论B3LYP，为H，C，P，O，N和Cl是6-31 + G（d，p）和用于钌，铁DGDZVP基组的）的1，2和还报告了3个。配合物1和2的特征是HOMO和LUMO在双金属配合物的以铁为中心的末端上离域。1 – 5的细胞毒性在A2780和A2780cisR（人类卵巢癌）细胞系和HEK293（人类胚胎肾脏）细胞系中进行了评估。在A2780细胞中，含铁的复合物比顺铂更具细胞毒性，在A2780cisR细胞系中的活性明显更高，并且对癌细胞具有一定的选择性。双核Ru，Ru复合物3和单核复合物4对A2780和A2780cisR细胞表现出中等活性，并且具有一些癌细胞选择性。因此，这项研究揭示了铁，钌配合物作为有效的细胞毒性剂的潜力。