Sketching neoteric solvents for boosting drugs bioavailability.,Journal of Controlled Release

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Sketching neoteric solvents for boosting drugs bioavailability.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2019-09-12 , DOI: 10.1016/j.jconrel.2019.09.008
María S Álvarez ₁ , Yanfei Zhang ₂

Affiliation

Emerging neoteric solvents are being the subject of growing attention due to their lower cost and environmental impact, so they are being applied in a broad spectrum of industries. Among them, the pharmaceutical sector is demanding new environmentally friendly and non-toxic solvents able to enhance drugs solubility and stability. The introduction of ionic liquids turned out to be a breakthrough in the field of Green Chemistry opening up new separation and catalysis opportunities. In this sense, the options represented by Deep Eutectic Solvents make up an attractive alternative due to the low cost of their raw material, simple synthesis, and eco-friendly character. In line with these findings, Therapeutic Deep Eutectic Solvents and Natural Deep Eutectic Solvents are new and promising alternatives to improve the bioavailability of drugs in pharmaceutical formulations. This leading article is focused on providing a general picture of the advantages and drawbacks of these new solvents as well as the main research lines and perspectives to achieve efficient drugs delivery systems.

中文翻译：

草绘新型溶剂，以提高药物的生物利用度。

新兴的现代溶剂由于其较低的成本和对环境的影响而受到越来越多的关注，因此它们被广泛地应用于各行各业。其中，制药行业需要能够增强药物溶解度和稳定性的新型环保无毒溶剂。引入离子液体被证明是绿色化学领域的突破，为分离和催化提供了新的机会。从这个意义上讲，由于其低廉的原料成本，简单的合成方法和环保特性，以深共晶溶剂为代表的选择是一个有吸引力的选择。根据这些发现，治疗性深共晶溶剂和天然深共晶溶剂是改善药物在药物制剂中的生物利用度的新的有希望的替代品。这篇主要文章着重于概述这些新型溶剂的优缺点，以及实现高效药物输送系统的主要研究方向和观点。

更新日期：2019-09-12

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