Methionine metabolism in health and cancer: a nexus of diet and precision medicine.,Nature Reviews Cancer

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Methionine metabolism in health and cancer: a nexus of diet and precision medicine.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2019-09-12 , DOI: 10.1038/s41568-019-0187-8
Sydney M Sanderson ₁ , Xia Gao ₁ , Ziwei Dai ₁ , Jason W Locasale ₁

Affiliation

Methionine uptake and metabolism is involved in a host of cellular functions including methylation reactions, redox maintenance, polyamine synthesis and coupling to folate metabolism, thus coordinating nucleotide and redox status. Each of these functions has been shown in many contexts to be relevant for cancer pathogenesis. Intriguingly, the levels of methionine obtained from the diet can have a large effect on cellular methionine metabolism. This establishes a link between nutrition and tumour cell metabolism that may allow for tumour-specific metabolic vulnerabilities that can be influenced by diet. Recently, a number of studies have begun to investigate the molecular and cellular mechanisms that underlie the interaction between nutrition, methionine metabolism and effects on health and cancer.

中文翻译：

健康和癌症中的蛋氨酸代谢：饮食和精准医学的关系。

蛋氨酸的摄取和代谢涉及许多细胞功能，包括甲基化反应、氧化还原维持、多胺合成和与叶酸代谢的偶联，从而协调核苷酸和氧化还原状态。在许多情况下，这些功能中的每一个都与癌症发病机制相关。有趣的是，从饮食中获得的蛋氨酸水平对细胞蛋氨酸代谢有很大影响。这在营养和肿瘤细胞代谢之间建立了联系，这可能会导致受饮食影响的肿瘤特异性代谢脆弱性。最近，许多研究已经开始研究构成营养、蛋氨酸代谢以及对健康和癌症的影响之间相互作用的分子和细胞机制。

更新日期：2019-09-12

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