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Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense.
Trends in Immunology ( IF 13.1 ) Pub Date : 2019-09-06 , DOI: 10.1016/j.it.2019.08.001 Thomas A Kufer 1 , Emma M Creagh 2 , Clare E Bryant 3
Trends in Immunology ( IF 13.1 ) Pub Date : 2019-09-06 , DOI: 10.1016/j.it.2019.08.001 Thomas A Kufer 1 , Emma M Creagh 2 , Clare E Bryant 3
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The mammalian innate immune system deals with invading pathogens and stress by activating pattern-recognition receptors (PRRs) in the host. Initially proposed to be triggered by the discrimination of defined molecular signatures from pathogens rather than from self, it is now clear that PRRs can also be activated by endogenous ligands, bacterial metabolites and, following pathogen-induced alterations of cellular processes, changes in the F-actin cytoskeleton. These processes are collectively referred to as effector-triggered immunity (ETI). Here, we summarize the molecular and conceptual advances in our understanding of cell autonomous innate immune responses against bacterial pathogens, and discuss how classical activation of PRRs and ETI interplay to drive inflammatory responses.
中文翻译：
细胞的监护人：效应触发的免疫引导哺乳动物免疫防御。
哺乳动物的先天免疫系统通过激活宿主中的模式识别受体（PRR）来应对入侵的病原体和压力。最初提出是通过区分病原体而不是自身的分子特征来触发的，现在很明显，PRR也可以被内源性配体，细菌代谢物激活，并且在病原体诱导的细胞过程改变后，F的改变-肌动蛋白细胞骨架。这些过程统称为效应触发免疫（ETI）。在这里，我们总结了对细菌病原体的细胞自主先天免疫应答的理解的分子和概念进展，并讨论了PRR和ETI的经典激活如何相互作用以驱动炎症反应。
更新日期：2019-09-30
中文翻译：
细胞的监护人：效应触发的免疫引导哺乳动物免疫防御。
哺乳动物的先天免疫系统通过激活宿主中的模式识别受体（PRR）来应对入侵的病原体和压力。最初提出是通过区分病原体而不是自身的分子特征来触发的，现在很明显，PRR也可以被内源性配体，细菌代谢物激活，并且在病原体诱导的细胞过程改变后，F的改变-肌动蛋白细胞骨架。这些过程统称为效应触发免疫（ETI）。在这里，我们总结了对细菌病原体的细胞自主先天免疫应答的理解的分子和概念进展，并讨论了PRR和ETI的经典激活如何相互作用以驱动炎症反应。
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