ZIF-67@Co-LDH yolk–shell spheres with micro-/meso-porous structures as vehicles for drug delivery†,Inorganic Chemistry Frontiers

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ZIF-67@Co-LDH yolk–shell spheres with micro-/meso-porous structures as vehicles for drug delivery†
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2019-09-06 , DOI: 10.1039/c9qi00801b
Liyong Chen _{1,

2,

3,

4,

5} , Jinfeng Wang _{1,

2,

3,

4} , Xiaoshuang Shen _{4,

6,

7,

8} , Xuezhao Li _{1,

2,

3,

4} , Chunying Duan _{1,

2,

3,

4}

Affiliation

ZIF-67@Co-LDH yolk–shell heterostructures are successfully synthesized by successive increase in Co²⁺ concentration in the methanolic solution of Co²⁺ and 2-methylimidazole (Hmim). This is mainly attributed to the slight difference in thermodynamic stability between ZIF-67 and Co-LDHs, accounting for the selective generation of Co-LDHs at a high molar ratio of Co²⁺ to Hmim. Co-LDH sheet assembled hydrophilic shells with mesoporous structures can control guest species shuttling between their interiors and exteriors, improving ZIF-67 stability and maintaining its reactivity as well in humid environments. Finally, hierarchical porous structures with high specific surface area are used to load the drug molecule model of rhodamine 6G to study drug delivery. The micro-/meso-porous structural ZIF-67@Co-LDH yolk–shell spheres exhibit a higher loading amount and longer release time compared to ZIF-67 nanocrystals or Co-LDH hollow spheres alone.

中文翻译：

具有微孔/中孔结构的ZIF-67 @ Co-LDH卵黄壳球作为药物输送的载体†

通过连续增加Co ²⁺和2-甲基咪唑（Hmim）的甲醇溶液中Co ^2+的浓度，成功合成了ZIF-67 @ Co-LDH卵黄壳结构。这主要归因于ZIF-67与Co-LDHs在热力学稳定性上的细微差别，这说明了在Co ²⁺的高摩尔比下选择性生成Co-LDHs的原因。到Hmim。具有中孔结构的Co-LDH板组装亲水壳可以控制客体物种在其内部和外部之间穿梭，从而提高ZIF-67的稳定性并在潮湿环境中保持其反应性。最后，具有高比表面积的分层多孔结构用于加载若丹明6G的药物分子模型以研究药物的递送。与单独的ZIF-67纳米晶体或Co-LDH中空球相比，微孔/中孔结构ZIF-67 @ Co-LDH卵黄壳球显示出更高的负载量和更长的释放时间。

更新日期：2019-11-06

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