2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated Tandem Oxidative Coupling/Intramolecular Annulation/Dehydro‐Aromatization for the Synthesis of Polysubstituted and Fused Pyridines,Advanced Synthesis & Catalysis

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2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated Tandem Oxidative Coupling/Intramolecular Annulation/Dehydro‐Aromatization for the Synthesis of Polysubstituted and Fused Pyridines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2019-09-19 , DOI: 10.1002/adsc.201900956
Dongping Cheng ₁ , Zhiteng Deng ₁ , Xianhang Yan ₁ , Mingliang Wang ₁ , Xiaoliang Xu ₂ , Jizhong Yan ₁

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A DDQ‐mediated tandem reaction of 1,3‐diarylpropenes and β‐enaminoesters/4‐aminocoumarins is disclosed. It involves oxidative coupling, intramolecular annulation and dehydro‐aromatization reaction, which provides an efficient and mild method for the synthesis of polysubstituted and fused pyridines under metal‐free conditions.

中文翻译：

2,3-二氯-5,6-二氰基-1,4-苯醌（DDQ）介导的串联氧化偶联/分子内环化/脱氢芳构化以合成多取代和熔融吡啶

披露了一种由DDQ介导的1,3-二芳基丙烯和β-氨基酯/ 4-氨基香豆素的串联反应。它涉及氧化偶联，分子内环化和脱氢芳香化反应，这为在无金属条件下合成多取代和稠合吡啶提供了一种有效而温和的方法。

更新日期：2019-09-19

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