DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides†,Organic Chemistry Frontiers

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DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2019-09-04 , DOI: 10.1039/c9qo00842j
Rongcong Ye _{1,

2,

3,

4} , Feiyue Hao _{1,

2,

3,

4} , Guyue Liu _{1,

2,

3,

4} , Qingsong Zuo _{1,

2,

3,

4} , Lijun Deng _{1,

2,

3,

4} , Zhengneng Jin _{1,

2,

3,

4} , Jiashou Wu _{1,

2,

3,

4}

Affiliation

We have developed a transition metal free method for efficient and chemoselective reduction of C [double bond, length as m-dash]

O bonds using DMF as a hydrogen source and solvent. α-Ketoamides bearing various functional groups are smoothly reduced to α-hydroxyamides in high yields with the present DMF/NaOH/H₂O reduction system.

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