It is challenging and urgent in neurosurgery to improve therapeutic effect of the most common and lethal malignant glioma in central nervous system. The superadditive therapeutic effect of photothermal therapy and photodynamic therapy holds great promise. Herein, a highly efficient photothermal-photodynamic therapy nanoplatform was developed on the basis of Fe₃O₄-IR806 superparticles. The introduction of the near-infrared (NIR) dye IR806 and the fabrication of the self-assembled structure of the superparticles warrant 3.5 times increase in the photothermal conversion efficiency compared with the Fe₃O₄ nanoparticles. The Fe₃O₄-IR806 superparticles generated reactive oxygen species (ROS) with the NIR light irradiation by virtue of the dye IR806. Both in vitro and in vivo experiments demonstrated that the Fe₃O₄-IR806 superparticles exhibited negligible toxicity. The Fe₃O₄-IR806 superparticles efficiently inhibited the cultured glioma cells via photothermal ablation and ROS cytotoxicity in vitro, as well as suppressed the bearing glioma growth in vivo with the NIR light induction. Our results highlight the promise of the Fe₃O₄-IR806 superparticles for improved photothermal-photodynamic therapy of cancer.

在神经外科中，提高中枢神经系统中最常见和致命的恶性神经胶质瘤的治疗效果具有挑战性和紧迫性。光热疗法和光动力疗法的超加和治疗作用具有广阔的前景。在此，基于Fe ₃ O ₄ -IR806超微粒，开发了高效的光热-光动力疗法纳米平台。与Fe ₃ O ₄纳米粒子相比，近红外（IR）染料IR806的引入和超粒子自组装结构的制造保证了光热转换效率提高了3.5倍。铁₃ O ₄-IR806超颗粒借助染料IR806在NIR光照射下生成活性氧（ROS）。体外和体内实验均表明，Fe ₃ O ₄ -IR806超颗粒的毒性可忽略不计。Fe ₃ O ₄ -IR806超微粒在体外通过光热消融和ROS细胞毒性有效抑制了培养的神经胶质瘤细胞，并通过NIR光诱导抑制了体内的神经胶质瘤的生长。我们的结果强调了Fe ₃ O ₄ -IR806超微粒有望改善癌症的光热-光动力疗法。