异烟肼负载线粒体靶向的WSSe / MnO2纳米复合材料的非芬顿型羟基自由基产生和光热效应，用于协同抗癌治疗。,Advanced Functional Materials

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异烟肼负载线粒体靶向的WSSe / MnO2纳米复合材料的非芬顿型羟基自由基产生和光热效应，用于协同抗癌治疗。
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-09-01 00:00:00 , DOI: 10.1002/adfm.201903850
Yaru Cheng _{1,

2} , Fan Yang _{1,

2} , Kai Zhang _{1,

3} , Yiyi Zhang _{1,

2} , Yu Cao _{1,

2} , Conghui Liu _{1,

2} , Huiting Lu ₄ , Haifeng Dong _{1,

2} , Xueji Zhang _{1,

2}

Affiliation

在此，根据Mn ²⁺离子催化的异烟肼（INH）的高反应性氧化羟基自由基（•OH）生成能力和WSSe纳米片的光热效应，开发了用于协同抗癌治疗的WSSe / MnO ₂ -INH纳米复合材料。在锰和相关的非芬顿型机理的存在下，系统地证明了先进的由INH诱导的•OH形成能力，以及WSSe / MnO ₂纳米复合材料具有良好的光热转化效率。用线粒体靶向的三苯基溴化膦（TPP）部分修饰并用癌细胞膜伪装后（WSSe / MnO ₂-INH-TPP @ CM），它赋予了连续的细胞到线粒体靶向能力。还显示了纳米复合材料的体内X射线计算机断层扫描和磁共振肿瘤成像能力。WSSe / MnO ₂ -INH-TPP @ CM的线粒体靶向氧化损伤和光热疗法在体内和体外均具有出色的抗癌治疗效果。这是首次探索非芬顿型•OH形成用于抗癌治疗的可能性，这为基于ROS的和联合的癌症治疗策略提供了新的机遇。

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Non‐Fenton‐Type Hydroxyl Radical Generation and Photothermal Effect by Mitochondria‐Targeted WSSe/MnO2 Nanocomposite Loaded with Isoniazid for Synergistic Anticancer Treatment

Here, in terms of the highly reactive oxidative hydroxyl radical (•OH) generation ability of isoniazid (INH) catalyzed by Mn²⁺ ion and the photothermal effect of WSSe nanoflakes, a WSSe/MnO₂‐INH nanocomposite for synergistic anticancer treatment is developed. Advanced INH‐induced •OH formation ability is systemically demonstrated in the presence of manganese and relevant non‐Fenton‐type mechanism, and good photothermal conversion efficiency of the WSSe/MnO₂ nanocomposite. After modifying with mitochondria‐targeted triphenylphosphonium bromide (TPP) moieties and camouflaging with cancer cells membrane (WSSe/MnO₂‐INH‐TPP@CM), it confers a sequential cell‐to‐mitochondria targeting ability. In vivo X‐ray computed tomography and magnetic resonance tumor imaging capability of the nanocomposite are also revealed. The mitochondria‐targeted oxidative damage and photothermal therapy by WSSe/MnO₂‐INH‐TPP@CM results in excellent anticancer treatment efficacy both in vitro and in vivo. This is the first exploration of the possibility of non‐Fenton‐type •OH formation for anticancer treatment, which opens new opportunities for ROS‐based and combined cancer treatment strategies.

更新日期：2019-11-06

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