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Tacamine-type alkaloids from Tabernaemontana bovina together with their configuration determination
Tetrahedron ( IF 2.1 ) Pub Date : 2019-08-28 , DOI: 10.1016/j.tet.2019.130562
Yang Yu , Mei-Fen Bao , Yi Wang , Ying Zeng , Xiang-Hai Cai

Eleven undescribed tacamine type alkaloids, named tabercamines A–K were isolated from leaves of Tabernaemontana bovina, together with six known alkaloids. The planar structure of the undescribed alkaloids were determined by comprehensive spectroscopic data analysis. Their absolute configuration were established based on the combination of the electronic circular dichroism and single X-ray crystal diffraction analysis. The NMR rules (in acetone-d6) of identifying of the stereo-configuration at C-20/16 was established.



中文翻译:

从Tacamine型生物碱狗牙花属bovina与它们的配置一起确定

11种未描述的他克胺型生物碱,称为塔伯卡明A–K ,与六个已知生物碱一起从藤的叶中分离出来。未描述的生物碱的平面结构通过综合光谱数据分析确定。基于电子圆二色性和单X射线晶体衍射分析的结合,确定了它们的绝对构型。建立了在C-20 / 16处确定立体构型的NMR规则(在丙酮中d 6)。

更新日期:2019-08-28
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