Nickel-Catalyzed Asymmetric Intramolecular Reductive Heck Reaction of Unactivated Alkenes.,Organic Letters

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Nickel-Catalyzed Asymmetric Intramolecular Reductive Heck Reaction of Unactivated Alkenes.
Organic Letters ( IF 4.9 ) Pub Date : 2019-08-28 00:00:00 , DOI: 10.1021/acs.orglett.9b02577
Feiyan Yang ₁ , Youxiang Jin ₁ , Chuan Wang ₁

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An asymmetric Ni-catalyzed intramolecular reductive Heck reaction of unactivated alkenes tethered to aryl bromides has been accomplished, providing a variety of benzene-fused cyclic compounds bearing a quaternary stereogenic center in good to excellent yields and high enantioselectivities. A mechanism has been proposed, which involves the enantiodetermining migratory insertion and the following protonation with water or alcoholic solvents as the proton source.

中文翻译：

镍催化未活化烯烃的不对称分子内还原性Heck反应。

已完成了将未活化烯烃束缚到芳基溴化物上的不对称Ni催化的分子内还原Heck反应，从而提供了多种具有季立体中心的苯稠合环状化合物，具有良好的产率和极高的对映选择性。已经提出了一种机制，其涉及对映体确定迁移插入以及随后用水或醇溶剂作为质子源的质子化。

更新日期：2019-08-28

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