Compound-Droplet-Pairs-Filled Hydrogel Microfiber for Electric-Field-Induced Selective Release.,Small

当前位置： X-MOL 学术 › Small › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Compound-Droplet-Pairs-Filled Hydrogel Microfiber for Electric-Field-Induced Selective Release.
Small ( IF 13.0 ) Pub Date : 2019-08-29 , DOI: 10.1002/smll.201903098
Xiaokang Deng ₁ , Yukun Ren _{1,

2} , Likai Hou ₁ , Weiyu Liu ₃ , Tianyi Jiang ₁ , Hongyuan Jiang _{1,

2}

Affiliation

The separate co-encapsulation and selective controlled release of multiple encapsulants in a predetermined sequence has potentially important applications for drug delivery and tissue engineering. However, the selective controlled release of distinct contents upon one triggering event for most existing microcarriers still remains challenging. Here, novel microfluidic fabrication of compound-droplet-pairs-filled hydrogel microfibers (C-Fibers) is presented for two-step selective controlled release under AC electric field. The parallel arranged compound droplets enable the separate co-encapsulation of distinct contents in a single microfiber, and the release sequence is guaranteed by the discrepancy of the shell thickness or core conductivity of the encapsulated droplets. This is demonstrated by using a high-frequency electric field to trigger the first burst release of droplets with higher conductivity or thinner shell, followed by the second release of the other droplets under low-frequency electric field. The reported C-Fibers provide novel multidelivery system for a wide range of applications that require controlled release of multiple ingredients in a prescribed sequence.

中文翻译：

电场诱导选择性释放的复合小滴对填充水凝胶超细纤维。

以预定的顺序分别包封和选择性释放多种密封剂对于药物输送和组织工程具有潜在的重要应用。然而，对于大多数现有的微载体，在一次触发事件后选择性地释放不同的内含物仍然具有挑战性。在这里，提出了复合液滴对填充的水凝胶微纤维（C纤维）的新型微流体制备，用于在交流电场下进行两步选择性控释。平行排列的复合液滴使单个微纤维中不同内容物的单独共囊化成为可能，并且释放顺序由囊状液滴的壳厚度或核心电导率的差异来保证。通过使用高频电场触发具有较高电导率或更薄的外壳的液滴的第一次爆发释放，然后在低频电场下第二次释放其他液滴，可以证明这一点。报道的C纤维为需要按规定顺序控制多种成分释放的广泛应用提供了新颖的多输送系统。

更新日期：2019-10-16

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南