Microporenic Acids A–G, Biofilm Inhibitors, and Antimicrobial Agents from the Basidiomycete Microporus Species,Journal of Natural Products

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Microporenic Acids A–G, Biofilm Inhibitors, and Antimicrobial Agents from the Basidiomycete Microporus Species
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-02-28 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00764
Clara Chepkirui ₁ , Kamila T. Yuyama ₂ , Lucy A. Wanga ₃ , Cony Decock ₄ , Josphat C. Matasyoh ₅ , Wolf-Rainer Abraham ₂ , Marc Stadler ₁

Affiliation

The need for effective compounds to combat antimicrobial resistance and biofilms which play important roles in human infections continues to pose a major health challenge. Seven previously undescribed acyclic diterpenes linked to isocitric acid by an ether linkage, microporenic acids A–G (1–7), were isolated from the cultures of a hitherto undescribed species of the genus Microporus (Polyporales, Basidiomycota) originating from Kenya’s Kakamega forest. Microporenic acids D and E (4 and 5) showed antimicrobial activity against a panel of Gram positive bacteria and a yeast, Candida tenuis. Moreover, microporenic acids A and B (1 and 2) demonstrated dose-dependent inhibition of biofilm formation by Staphylococcus aureus. Compound 1 further showed significant activity against Candida albicans and Staphylococcus aureus preformed biofilms.

中文翻译：

Microporenic酸A-G，生物膜抑制剂和抗微生物剂从担子菌纲Microporus物种

需要有效的化合物来对抗在人类感染中起重要作用的抗微生物剂耐药性和生物膜，这仍然构成了重大的健康挑战。七先前由醚键未描述连接到异柠檬酸的无环双萜，microporenic酸A-G（1 - 7），从该属的一个迄今未描述的物种的培养物中分离Microporus（多孔菌，担子菌门）从肯尼亚的卡卡梅加森林始发。微孔酸D和E（4和5）对一组革兰氏阳性细菌和酵母假丝酵母（Candida tenuis）显示出抗菌活性。此外，微孔酸A和B（1和2）证明了金黄色葡萄球菌对生物膜形成的剂量依赖性抑制作用。化合物1还显示出对白色念珠菌和金黄色葡萄球菌预先形成的生物膜的显着活性。

更新日期：2018-02-28

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