Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells.,Nature Reviews Cancer

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Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2019-08-27 , DOI: 10.1038/s41568-019-0180-2
Laura Keller ₁ , Klaus Pantel ₁

Affiliation

Single-cell technologies have contributed to unravelling tumour heterogeneity, now considered a hallmark of cancer and one of the main causes of tumour resistance to cancer therapies. Liquid biopsy (LB), defined as the detection and analysis of cells or cell products released by tumours into the blood, offers an appealing minimally invasive approach that allows the characterization and monitoring of tumour heterogeneity in individual patients. Here, we will review and discuss how circulating tumour cell (CTC) analysis at single-cell resolution provides unique insights into tumour heterogeneity that are not revealed by analysis of circulating tumour DNA (ctDNA) derived from LBs. The molecular analysis of CTCs provides complementary information to that of genomic aberrations determined using ctDNA to fully describe many different cellular components (for example, DNA, RNA, proteins and metabolites) that can influence tumour heterogeneity.

中文翻译：

通过循环肿瘤细胞的单细胞分析揭示肿瘤异质性。

单细胞技术有助于揭示肿瘤异质性，现在被认为是癌症的标志，也是肿瘤对癌症治疗产生耐药性的主要原因之一。液体活检 (LB) 定义为检测和分析肿瘤释放到血液中的细胞或细胞产物，它提供了一种有吸引力的微创方法，可以对个体患者的肿瘤异质性进行表征和监测。在这里，我们将回顾和讨论单细胞分辨率的循环肿瘤细胞 (CTC) 分析如何提供对肿瘤异质性的独特见解，而这些见解无法通过分析源自 LB 的循环肿瘤 DNA (ctDNA) 揭示。

更新日期：2019-08-27

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