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A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila.
Neuron ( IF 14.7 ) Pub Date : 2019-08-27 , DOI: 10.1016/j.neuron.2019.07.028 Sercan Sayin 1 , Jean-Francois De Backer 1 , K P Siju 1 , Marina E Wosniack 2 , Laurence P Lewis 3 , Lisa-Marie Frisch 1 , Benedikt Gansen 1 , Philipp Schlegel 4 , Amelia Edmondson-Stait 4 , Nadiya Sharifi 5 , Corey B Fisher 5 , Steven A Calle-Schuler 5 , J Scott Lauritzen 5 , Davi D Bock 5 , Marta Costa 4 , Gregory S X E Jefferis 6 , Julijana Gjorgjieva 2 , Ilona C Grunwald Kadow 7
Neuron ( IF 14.7 ) Pub Date : 2019-08-27 , DOI: 10.1016/j.neuron.2019.07.028 Sercan Sayin 1 , Jean-Francois De Backer 1 , K P Siju 1 , Marina E Wosniack 2 , Laurence P Lewis 3 , Lisa-Marie Frisch 1 , Benedikt Gansen 1 , Philipp Schlegel 4 , Amelia Edmondson-Stait 4 , Nadiya Sharifi 5 , Corey B Fisher 5 , Steven A Calle-Schuler 5 , J Scott Lauritzen 5 , Davi D Bock 5 , Marta Costa 4 , Gregory S X E Jefferis 6 , Julijana Gjorgjieva 2 , Ilona C Grunwald Kadow 7
Affiliation
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In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive.
中文翻译：
饥饿果蝇的持久性和退出之间的神经回路仲裁。
为了追求食物，饥饿的动物调动了大量的能量资源，克服了疲惫和恐惧。需要和动机如何控制继续或改变行为的决定尚不清楚。使用单飞跑步机，我们表明饥饿的苍蝇持续追踪食物气味，并在没有奖励的情况下通过重复试验增加努力，这表明需要支配负面体验。我们进一步表明气味跟踪是由连接 MB 和侧角的两个蘑菇体输出神经元 (MBON) 调节的。这些 MBON 与多巴胺能神经元和 Dop1R2 信号一起控制行为持久性。相反，直接支配其中一个 MBON 的章鱼胺能神经元 VPM4 通过连接进食和嗅觉来抑制气味跟踪。一起，
更新日期：2019-09-30
中文翻译：
饥饿果蝇的持久性和退出之间的神经回路仲裁。
为了追求食物，饥饿的动物调动了大量的能量资源，克服了疲惫和恐惧。需要和动机如何控制继续或改变行为的决定尚不清楚。使用单飞跑步机，我们表明饥饿的苍蝇持续追踪食物气味，并在没有奖励的情况下通过重复试验增加努力，这表明需要支配负面体验。我们进一步表明气味跟踪是由连接 MB 和侧角的两个蘑菇体输出神经元 (MBON) 调节的。这些 MBON 与多巴胺能神经元和 Dop1R2 信号一起控制行为持久性。相反，直接支配其中一个 MBON 的章鱼胺能神经元 VPM4 通过连接进食和嗅觉来抑制气味跟踪。一起，
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