Bifunctional Ion Pair Catalysts from Chiral α‐Amino Acids,Chinese Journal of Chemistry

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Bifunctional Ion Pair Catalysts from Chiral α‐Amino Acids
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2019-09-12 , DOI: 10.1002/cjoc.201900276
Hongyu Wang ₁ , Changwu Zheng _{2,

3} , Gang Zhao ₂

Affiliation

Asymmetric ion pair catalysis presents a powerful strategy for the construction of chiral molecules. However, the ion‐pair interactions are weakly directional and result in difficultly controlling the conformational constraint for high stereo‐ inductions. Based on the hydrogen bonding interactions, we have successfully designed and synthesized a new family of bifunctional ion pair catalysts derived from chiral amino acids via simple operations. With these chiral ammonium salts and phosphonium salts in hand, the enantioselective construction of C—C and C—X bonds was realized in our lab.

中文翻译：

手性α-氨基酸的双功能离子对催化剂

不对称离子对催化为手性分子的构建提供了强有力的策略。但是，离子对相互作用的方向性较弱，导致难以控制构象约束以实现高立体感应。基于氢键相互作用，我们已经成功设计并合成了一系列新的双官能离子对催化剂，它们通过简单的操作衍生自手性氨基酸。有了这些手性铵盐和phospho盐，在我们的实验室中实现了C和C X键的对映选择性结构。

更新日期：2019-09-12

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