Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.,Molecular Nutrition & Food Research

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Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2019-09-01 , DOI: 10.1002/mnfr.201900629
Juan Antonio Giménez-Bastida ₁ , María Ángeles Ávila-Gálvez ₁ , Juan Carlos Espín ₁ , Antonio González-Sarrías ₁

Affiliation

Recent evidence demonstrates that resveratrol (RSV) metabolites, but not free RSV, reach malignant tumors (MT) in breast cancer (BC) patients. Since these metabolites, as detected in MT, do not exert short‐term antiproliferative or estrogenic/antiestrogenic activities, long‐term tumor‐senescent chemoprevention has been hypothesized. Consequently, here, for the first time, whether physiologically relevant RSV metabolites can induce senescence in BC cells is investigated.

中文翻译：

共轭的生理白藜芦醇代谢物在乳腺癌细胞中诱导衰老：p53 / p21和p16 / Rb途径以及ABC转运蛋白的作用。

最近的证据表明，白藜芦醇（RSV）代谢产物而非游离RSV会在乳腺癌（BC）患者中达到恶性肿瘤（MT）。由于在MT中检测到的这些代谢物没有发挥短期的抗增殖或雌激素/抗雌激素活性，因此已假设可以长期预防肿瘤衰老的化学作用。因此，在这里，首次研究了生理学上相关的RSV代谢物是否可以诱导BC细胞衰老。

更新日期：2019-09-01

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