AIE 活性功能化丙烯腈：通过简单反应条件变化、高效红光发射和双光子生物成像进行结构调整,Journal of the American Chemical Society

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AIE 活性功能化丙烯腈：通过简单反应条件变化、高效红光发射和双光子生物成像进行结构调整
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2019-08-22 , DOI: 10.1021/jacs.9b06196
Guangle Niu _{1,

2} , Xiuli Zheng ₃ , Zheng Zhao ₂ , Haoke Zhang ₂ , Jianguo Wang ₂ , Xuewen He ₂ , Yuncong Chen _{1,

2} , Xiujuan Shi _{1,

2} , Chao Ma ₄ , Ryan T K Kwok _{1,

2} , Jacky W Y Lam _{1,

2} , Herman H Y Sung ₂ , Ian D Williams ₂ , Kam Sing Wong ₄ , Pengfei Wang ₃ , Ben Zhong Tang _{1,

2,

5}

Affiliation

已发现具有聚集诱导发射 (AIE) 特性的丙烯腈在双光子生物医学成像中显示出有前景的应用。通常，需要精心合成才能获得具有不同功能的不同丙烯腈。在这项工作中，我们首先报道了两种不同的基团官能化的 AIE 活性丙烯腈（TPAT-AN-XF 和 2TPAT-AN）的合成，这些丙烯腈是通过在不同温度下使用简便且不含过渡金属的方法混合相同的反应物而获得的。合成方法。这两种 AIE 发光体 (AIEgens) 表现出独特的特性，例如固态下的亮红色发射、大斯托克斯位移和大双光子吸收截面。通过纳米沉淀法制备了2TPAT-CN的水溶性纳米颗粒（NPs）。体外成像数据表明，2TPAT-CN NPs 可以选择性地染色活细胞中的溶酶体。除了单光子成像外，还可以通过高分辨率和深层组织穿透实现对活肿瘤组织的显着双光子成像。2TPAT-CN NPs 显示出高生物相容性，并成功地用于小鼠肿瘤的体内长期成像，具有高信噪比。因此，目前的工作有望阐明具有有趣的生物医学应用特性的 AIE 活性官能化丙烯腈库的制备。2TPAT-CN NPs 显示出高生物相容性，并成功地用于小鼠肿瘤的体内长期成像，具有高信噪比。因此，目前的工作有望阐明具有有趣的生物医学应用特性的 AIE 活性官能化丙烯腈库的制备。2TPAT-CN NPs 显示出高生物相容性，并成功地用于小鼠肿瘤的体内长期成像，具有高信噪比。因此，目前的工作有望阐明具有有趣的生物医学应用特性的 AIE 活性官能化丙烯腈库的制备。

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AIE-Active Functionalized Acrylonitriles: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission and Two-Photon Bioimaging

Acrylonitriles with aggregation-induced emission (AIE) characteristics have found to show promising applications in two-photon biomedical imaging. Generally, elaborate synthetic efforts are required to achieve different acrylonitriles with dis-tinct functionalities. In this work, we first reported the synthesis of two different group-functionalized AIE-active acrylo-nitriles (TPAT-AN-XF and 2TPAT-AN) obtained simply by mixing the same reactants at different temperature using a facile and transition metal-free synthetic method. These two AIE luminogens (AIEgens) exhibit unique properties such as bright red emission in the solid state, large Stokes shift and large two-photon absorption cross section. Water-soluble nanoparticles (NPs) of 2TPAT-CN were prepared by nanoprecipitation method. In vitro imaging data show that 2TPAT-CN NPs can selectively stain lysosome in live cells. Besides one-photon imaging, remarkable two-photon imaging of live tumor tissues can be achieved with high resolution and deep tissue penetration. 2TPAT-CN NPs show high biocompati-bility and are successfully utilized in in vivo long-term imaging of mouse tumor with high signal-to-noise ratio. Thus, the present work is anticipated to shed light on the preparation of a library of AIE-active functionalized acrylonitriles with intriguing properties for biomedical applications.

更新日期：2019-08-22

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