Synthesis of 2,4‐Diaryl‐1,3‐benzoxazines via FeCl3‐Catalyzed Annulation of ortho‐Hydroxyphenyl‐Substituted para‐Quinone Methides with Imidates,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of 2,4‐Diaryl‐1,3‐benzoxazines via FeCl3‐Catalyzed Annulation of ortho‐Hydroxyphenyl‐Substituted para‐Quinone Methides with Imidates
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2019-09-06 , DOI: 10.1002/adsc.201900842
Jing‐Ru Zhang ₁ , Hai‐Shan Jin ₁ , Ru‐Bing Wang ₂ , Li‐Ming Zhao _{1,

2}

Affiliation

A strategy has been established for the synthesis of 2,4‐diaryl‐1,3‐benzoxazines via a FeCl₃‐catalyzed annulation of ortho‐hydroxyphenyl‐substituted para‐quinone methides (p‐QMs) and imidates. This transformation proceeds under mild, operationally‐simple conditions in a very short time. A wide range of substrates was accessed in this facile chemical transformation, in which the cyclized products were isolated in good to excellent yields (37% to 98%). This reaction not only provides an efficient method for the construction of biologically important 2,4‐diaryl‐1,3‐benzoxazines but also greatly enriches the chemistry of p‐QMs.

中文翻译：

FeCl ₃催化的邻羟基苯酚取代的对苯二甲酰亚胺与亚酰胺的环化反应合成2,4-二芳基-1,3-苯并恶嗪

已经建立了通过FeCl ₃催化的邻-羟基苯基取代的对-醌甲基化物（p- QMs）和酰亚胺化合成2,4-二芳基-1,3-苯并恶嗪的策略。这种转变是在很短的时间内，在温和的，操作简单的条件下进行的。在这种简便的化学转化过程中，可以得到各种各样的底物，其中以良好至极好的收率（37％至98％）分离出环化产物。该反应不仅为构建生物学上重要的2,4-二芳基-1,3-苯并恶嗪提供了一种有效的方法，而且大大丰富了p- QM的化学性质。

更新日期：2019-09-06

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南