Synthesis ( IF 2.2 ) Pub Date : 2019-08-21 , DOI: 10.1055/s-0039-1690182 M. Loubidi 1, 2 , M. Lorion 3 , A. El Hakmaoui 2 , P. Bernard 3 , M. Akssira 2 , G. Guillaumet 1
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Abstract
In this work, we continue our adventure in the chemistry of 5-5 tri-nitrogen bicycles. We disclose herein a one-step reaction to synthesize 1H-imidazo[1,5-a]imidazoles with different substituents introduced through the use of a wide range of aldehydes and isocyanides by using a Groebke–Blackburn–Bienaymé multicomponent reaction. The aim is to build a new library of 1H-imidazo[1,5-a]imidazole scaffolds. This bicycle was then modified to access new nitrogen-containing polycyclic compounds.
In this work, we continue our adventure in the chemistry of 5-5 tri-nitrogen bicycles. We disclose herein a one-step reaction to synthesize 1H-imidazo[1,5-a]imidazoles with different substituents introduced through the use of a wide range of aldehydes and isocyanides by using a Groebke–Blackburn–Bienaymé multicomponent reaction. The aim is to build a new library of 1H-imidazo[1,5-a]imidazole scaffolds. This bicycle was then modified to access new nitrogen-containing polycyclic compounds.
中文翻译：
1H-咪唑并[1,5-a]咪唑支架的一步合成及其接近的多杂环化合物
抽象的
在这项工作中，我们将继续探索5-5三氮自行车的化学过程。我们在本文中公开了一步反应，通过使用Groebke-Blackburn-Bienaymé多组分反应合成具有不同取代基的1 H-咪唑并[1,5- a ]咪唑，这些取代基是通过使用多种醛和异氰酸酯引入的。目的是建立一个新的1 H-咪唑并[1,5- a ]咪唑支架的文库。然后对这辆自行车进行了改装，以使用新的含氮多环化合物。
在这项工作中，我们将继续探索5-5三氮自行车的化学过程。我们在本文中公开了一步反应，通过使用Groebke-Blackburn-Bienaymé多组分反应合成具有不同取代基的1 H-咪唑并[1,5- a ]咪唑，这些取代基是通过使用多种醛和异氰酸酯引入的。目的是建立一个新的1 H-咪唑并[1,5- a ]咪唑支架的文库。然后对这辆自行车进行了改装，以使用新的含氮多环化合物。
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