The first total synthesis of rhuscholide A, a benzofuran lactone possessing anti-HIV-1 activity, had been accomplished in 14 linear steps with 10.6% overall yield. In this synthesis, base-mediated phenol ortho-alkylation and piperidine promoted aldol condensation were exploited as key steps. The synthesis was flexible and allowed for the convenient preparation of two analogous natural products glabralide B and denudalide.

中文翻译：

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首次全合成鼠李糖苷A，glabralide B和denudalide

具有14个线性步骤，以14.6％的总收率完成了具有抗HIV-1活性的苯并呋喃内酯Rhuscholide A的第一个全合成。在该合成中，将碱介导的苯酚正烷基化和哌啶促进的醇醛缩合用作关键步骤。该合成是灵活的，并且允许方便地制备两种类似的天然产物glabralide B和denudalide。