Prospects, challenges and current status of RNAi through insect feeding.,Pest Management Science

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Prospects, challenges and current status of RNAi through insect feeding.
Pest Management Science ( IF 3.8 ) Pub Date : 2019-09-17 , DOI: 10.1002/ps.5588
Nitish Kunte ₁ , Erin McGraw ₁ , Sydney Bell ₁ , David Held ₂ , Luz-Adriana Avila ₁

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RNA interference is a phenomenon in which the introduction of double-stranded RNA (dsRNA) into cells triggers the degradation of the complementary messenger RNA in a sequence-specific manner. Suppressing expression of vital genes could lead to insect death, therefore this technology has been considered as a potential strategy for insect pest control. There are three main routes of dsRNA administration into insects: (i) injections to the hemolymph, (ii) topical, and (iii) feeding. In this review, we focus on dsRNA administration through feeding. We summarize novel strategies that have been developed to improve the efficacy of this method, such as the use of nano-based formulations, engineered microorganisms, and transgenic plants. We also expose the hurdles that have to be overcome in order to use this technique as a reliable pest management method. © 2019 Society of Chemical Industry.

中文翻译：

通过昆虫取食，RNAi的前景，挑战和现状。

RNA干扰是一种现象，其中将双链RNA（dsRNA）引入细胞会以序列特异性方式触发互补信使RNA的降解。抑制重要基因的表达可能导致昆虫死亡，因此该技术被认为是控制害虫的一种潜在策略。dsRNA进入昆虫的途径主要有以下三种：（i）注射淋巴液；（ii）局部用药；（iii）喂养。在这篇综述中，我们专注于通过饲喂进行dsRNA施用。我们总结了已开发出的改善该方法功效的新策略，例如使用基于纳米的配方，工程微生物和转基因植物。我们还揭露了使用该技术作为可靠的有害生物管理方法必须克服的障碍。

更新日期：2019-09-17

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