In this study, a continuous-flow coupling reaction method has been developed for the synthesis of Pigment Red 146 (C.I. PR 146). A computational fluid dynamics simulation was used to evaluate the effects of the micromixer structures on the mixing process. After the optimization of the microreactor structures and the reaction conditions, the conversion of the coupling reaction reached more than 99% using a microsieve pore dispersion reactor (two microsieve pores arranged side by side) and a smaller particle size and narrower particle-size distribution were obtained than were obtained in conventional batch reactors. Furthermore, the lightness and the green and the blue hues of these pigment products were more intense than those of the C.I. PR 146 standard. The largest conformity of the hue of the pigment products compared with the C.I. PR 146 standard was obtained using a microsieve pore dispersion reactor under the optimized reaction conditions. Finally, a scaling-up study of the pigment synthesis process in the microreactor system was initially explored. In conclusion, the microreactor system led to an improvement of the pigment products, and this method has a good industrial value.

中文翻译：

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微反应器系统中连续流合成颜料红146

在这项研究中，已开发出一种连续流偶合反应方法来合成颜料红146（CI PR 146）。使用计算流体动力学模拟来评估微混合器结构对混合过程的影响。在优化了微反应器的结构和反应条件后，使用微筛孔分散反应器（两个微筛孔并排布置）使偶联反应的转化率达到99％以上，并且粒径较小，粒径分布较窄与常规间歇反应器中获得的相比。此外，这些颜料产品的亮度以及绿色和蓝色调都比CI PR 146标准强。与CI相比，颜料产品的色相具有最大的一致性 使用微筛孔分散反应器在优化的反应条件下获得PR 146标准品。最后，最初探索了微反应器系统中颜料合成过程的放大研究。总之，微反应器系统导致了颜料产品的改进，并且该方法具有良好的工业价值。