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Polyhydroxy cucurbitane triterpenes from Hemsleya penxianensis tubers.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-08-14 , DOI: 10.1038/s41598-019-48365-0 Zhaocui Sun 1 , Meigeng Hu 1 , Nailiang Zhu 1 , Xiaowei Huo 2 , Xiaolei Zhou 1 , Zhonghao Sun 1 , Junshan Yang 1 , Guoxu Ma 1 , Xudong Xu 1
Scientific Reports ( IF 3.8 ) Pub Date : 2019-08-14 , DOI: 10.1038/s41598-019-48365-0 Zhaocui Sun 1 , Meigeng Hu 1 , Nailiang Zhu 1 , Xiaowei Huo 2 , Xiaolei Zhou 1 , Zhonghao Sun 1 , Junshan Yang 1 , Guoxu Ma 1 , Xudong Xu 1
Affiliation
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Ten new cucurbitane triterpenoids, hemsleyacins A-J (1-10), together with three known cucurbitane triterpenoids, dihydrocucurbitacin F (11), scandenogenin D (12), and jinfushanencin F (13), were separated from ethanolic tuber extracts of Hemsleya penxianensis. The absolute configurations of the new compounds were established based on NMR, HRESIMS, and CD spectra. Compounds 7 and 10-12 were evaluated in terms of their antifeedant activity against Plutella xylostella larvae. The result showed that compound 10 exhibited potent antifeedant activity against P. xylostella larvae after 48 h of treatment. Furthermore, the MTT test showed that compound 11 exhibited potent inhibition toward the UMUC-3 and T24 cell lines with IC50 values of 29.12 and 35.62 μM, respectively, compared to the positive control cisplatin IC50 values of 8.27 and 13.72 μM. Western blot analysis revealed that compound 11 treatments substantially inhibited the phosphorylation of IκBα.
中文翻译：
八角萱草块茎的多羟基葫芦烷三萜。
从五味萱草的乙醇块茎提取物中分离出十种新的葫芦形三萜类化合物Hemsleyacins AJ（1-10），以及三种已知的葫芦形三萜类化合物Dihydrocucurbitacin F（11），scandenogenin D（12）和jinfushanencin F（13）。基于NMR，HRESIMS和CD光谱确定了新化合物的绝对构型。根据化合物对小菜蛾幼虫的拒食活性来评价化合物7和10-12。结果表明，在处理48小时后，化合物10对小菜蛾幼虫表现出强效的拒食活性。此外，MTT测试表明，与阳性对照顺铂IC50值为8.27和13.72μM相比，化合物11对UMUC-3和T24细胞系表现出强抑制作用，IC50值分别为29.12和35.62μM。
更新日期：2019-08-14
中文翻译：
八角萱草块茎的多羟基葫芦烷三萜。
从五味萱草的乙醇块茎提取物中分离出十种新的葫芦形三萜类化合物Hemsleyacins AJ（1-10），以及三种已知的葫芦形三萜类化合物Dihydrocucurbitacin F（11），scandenogenin D（12）和jinfushanencin F（13）。基于NMR，HRESIMS和CD光谱确定了新化合物的绝对构型。根据化合物对小菜蛾幼虫的拒食活性来评价化合物7和10-12。结果表明，在处理48小时后，化合物10对小菜蛾幼虫表现出强效的拒食活性。此外，MTT测试表明，与阳性对照顺铂IC50值为8.27和13.72μM相比，化合物11对UMUC-3和T24细胞系表现出强抑制作用，IC50值分别为29.12和35.62μM。
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