Crystal structure of a NIR-Emitting DNA-Stabilized Ag16 Nanocluster.,Angewandte Chemie International Edition

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Crystal structure of a NIR-Emitting DNA-Stabilized Ag16 Nanocluster.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-09-10 , DOI: 10.1002/anie.201906766
Cecilia Cerretani ₁ , Hiroki Kanazawa _{2,

3} , Tom Vosch ₁ , Jiro Kondo ₂

Affiliation

DNA has been used as a scaffold to stabilize small, atomically monodisperse silver nanoclusters, which have attracted attention due to their intriguing photophysical properties. Herein, we describe the X-ray crystal structure of a DNA-encapsulated, near-infrared emitting Ag16 nanocluster (DNA-Ag16 NC). The asymmetric unit of the crystal contains two DNA-Ag16 NCs and the crystal packing between the DNA-Ag16 NCs is promoted by several interactions, such as two silver-mediated base pairs between 3'-terminal adenines, two phosphate-Ca2+ -phosphate interactions, and π-stacking between two neighboring thymines. Each Ag16 NC is confined by two DNA decamers that take on a horse-shoe-like conformation and is almost fully shielded from the solvent environment. This structural insight will aid in the determination of the structure/photophysical property relationship for this class of emitters and opens up new research opportunities in fluorescence imaging and sensing using noble-metal clusters.

中文翻译：

发射近红外光的DNA稳定的Ag16纳米簇的晶体结构。

DNA已被用作稳定小原子单分散银纳米团簇的支架，这些团簇因其有趣的光物理特性而引起了人们的关注。在这里，我们描述了DNA封装的，发射近红外光的Ag16纳米簇（DNA-Ag16 NC）的X射线晶体结构。晶体的不对称单元包含两个DNA-Ag16 NCs，DNA-Ag16 NCs之间的晶体堆积通过多种相互作用促进，例如3'-末端腺嘌呤之间的两个银介导的碱基对，两个磷酸盐-Ca2 +-磷酸盐相互作用，以及两个相邻胸腺嘧啶之间的π堆积。每个Ag16 NC均由两个呈马蹄形构象的DNA十聚体限制，几乎完全被溶剂环境屏蔽。

更新日期：2019-09-10

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