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Prunus Mahaleb Fruit Extract Prevents Chemically Induced Colitis and Enhances Mitochondrial Oxidative Metabolism via the Activation of the Nrf2 Pathway.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2019-08-22 , DOI: 10.1002/mnfr.201900350
Alessandra Ferramosca 1 , Lucia Treppiccione 2 , Mariangela Di Giacomo 1 , Vera Rotondi Aufiero 2 , Giuseppe Mazzarella 2 , Francesco Maurano 2 , Carmela Gerardi 3 , Mauro Rossi 2 , Vincenzo Zara 1 , Giovanni Mita 3 , Paolo Bergamo 2
Affiliation  

Polyphenols exhibit their antioxidant activity downstream the activation of the nuclear factor erythroid 2‐related factor 2 pathway (Nrf2), but the connection between lipid metabolism and the Nrf2 pathway is still unknown. Flavonoid‐rich concentrated extract from Prunus mahaleb (mahaleb concentrated fruit extract; MCFE) may act on oxido‐reductive homeostasis and hepatic lipid metabolism via Nrf2.

中文翻译:

李桃果实提取物可通过激活Nrf2途径预防化学性结肠炎并增强线粒体氧化代谢。

多酚在核因子红系2相关因子2途径(Nrf2)激活的下游具有抗氧化活性,但是脂质代谢和Nrf2途径之间的联系仍然未知。樱桃李的富含类黄酮的浓缩提取物(mahaleb浓缩的水果提取物; MCFE)可能通过Nrf2作用于氧化还原稳态和肝脂质代谢。
更新日期:2019-08-22
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