Lanthanide coordination nanoparticles terbium(III) (Tb³⁺)-based fluorescent nanoparticles (luminol-Tb NPs) are synthesized via aggregation-induced fluorescence strategy. Fluorescence of luminol-Tb NPs is enhanced nearly 40 times compared with luminol, which is the effect of aggregation-induced fluorescence by Tb³⁺. Luminol-Tb NPs with high fluorescence is utilized in fluorescent “turn-off” detection of uric acid (UA) within 1 min from 0.1 to 50 μM with the limit of detection (LOD) of 28 nM. The fluorescence quenching effect may be ascribed to photoinduced electron transfer occurs from luminol-Tb NPs to UA. This fluorescent method exhibits high selectivity in UA detection towards metal ions, glucose, ascorbic acid, dopamine, creatinine, urea and cysteine. When it is also applied in detection of UA in serum samples, 5 μM, 10 μM and 30 μM UA are respectively added to serum samples and recoveries range from 97.5% to 101.3% in serum samples. It demonstrates the practical value of luminol-Tb NPs for UA detection in serum.

通过聚集诱导的荧光策略合成镧系配位纳米粒子ter（Tb ³⁺）基荧光纳米粒子（鲁米诺-Tb NPs）。与鲁米诺相比，鲁米诺-Tb NPs的荧光增强了近40倍，这是Tb ³⁺聚集诱导的荧光作用。具有高荧光性的Luminol-Tb NPs可在0.1分钟至50μM的1分钟内对尿酸（UA）进行荧光“关闭”检测，检测限（LOD）为28 nM。荧光猝灭作用可归因于从鲁米诺-Tb NPs到UA的光诱导电子转移。这种荧光方法在UA检测中对金属离子，葡萄糖，抗坏血酸，多巴胺，肌酐，尿素和半胱氨酸具有很高的选择性。当它也用于血清样品中UA的检测时，分别向血清样品中添加5μM，10μM和30μMUA，血清样品中的回收率在97.5％至101.3％之间。它证明了鲁米诺-Tb NPs在血清UA检测中的实用价值。