Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Impact of maternal characteristics on human milk oligosaccharide composition over the first 4 months of lactation in a cohort of healthy European mothers.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-08-13 , DOI: 10.1038/s41598-019-48337-4 Tinu Mary Samuel 1 , Aristea Binia 1 , Carlos Antonio de Castro 2 , Sagar K Thakkar 1 , Claude Billeaud 3 , Massimo Agosti 4 , Isam Al-Jashi 5 , Maria Jose Costeira 6 , Giovanna Marchini 7 , Cecilia Martínez-Costa 8 , Jean-Charles Picaud 9 , Tom Stiris 10 , Silvia-Maria Stoicescu 11 , Mireille Vanpeé 7 , Magnus Domellöf 12 , Sean Austin 1 , Norbert Sprenger 1
Scientific Reports ( IF 3.8 ) Pub Date : 2019-08-13 , DOI: 10.1038/s41598-019-48337-4 Tinu Mary Samuel 1 , Aristea Binia 1 , Carlos Antonio de Castro 2 , Sagar K Thakkar 1 , Claude Billeaud 3 , Massimo Agosti 4 , Isam Al-Jashi 5 , Maria Jose Costeira 6 , Giovanna Marchini 7 , Cecilia Martínez-Costa 8 , Jean-Charles Picaud 9 , Tom Stiris 10 , Silvia-Maria Stoicescu 11 , Mireille Vanpeé 7 , Magnus Domellöf 12 , Sean Austin 1 , Norbert Sprenger 1
Affiliation
|
Human milk oligosaccharide (HMO) composition varies among lactating mothers and changes during the course of lactation period. Interindividual variation is largely driven by fucosyltransferase (FUT2 and FUT3) polymorphisms resulting in 4 distinct milk groups. Little is known regarding whether maternal physiological status contributes to HMO variability. We characterized the trajectories of 20 major HMOs and explored whether maternal pre-pregnancy body mass index (ppBMI), mode of delivery, or parity may affect milk HMO composition. Using longitudinal breastmilk samples from healthy mothers (n = 290) across 7 European countries, we characterized HMO composion and employed mixed linear models to explore associations of maternal characteristics with individual HMOs. We observed HMO-specific temporal trajectories and milk group dependencies. We observed relatively small but significant differences in HMO concentrations based on maternal ppBMI, mode of delivery and parity. Our findings suggest that HMO composition to be regulated time-dependently by an enzyme as well as substrate availability and that ppBMI, mode of delivery, and parity may influence maternal physiology to affect glycosylation marginally within the initital period of lactation. Our observational study is the largest European standardized and longitudinal (up to 4 months) milk collection study assessing HMO concentrations and basic maternal characteristics. Time of lactation and milk groups had the biggest impact on HMO variation. Future studies need to elucidate these observations and assess the physiological significance for the breastfed infant.
中文翻译：
一群健康的欧洲母亲在哺乳期的前四个月中，母性特征对人乳寡糖组成的影响。
母乳中的人乳低聚糖（HMO）组成各不相同，并且在哺乳期间会发生变化。个体间的差异主要由岩藻糖基转移酶（FUT2和FUT3）多态性驱动，导致4个不同的牛奶组。关于孕产妇的生理状况是否会导致HMO变异性知之甚少。我们对20种主要HMO的轨迹进行了表征，并探讨了孕妇孕前体重指数（ppBMI），分娩方式或均价是否会影响牛奶HMO的组成。我们使用来自七个欧洲国家/地区的健康母亲（n = 290）的纵向母乳样本，对HMO组成进行了表征，并采用混合线性模型探索了孕产妇特征与单个HMO的关联。我们观察到了HMO特定的时间轨迹和牛奶群的依赖性。我们观察到基于母体ppBMI，分娩方式和均价的HMO浓度相对较小但存在显着差异。我们的发现表明，HMO组成受酶以及底物可用性的影响呈时间依赖性，并且ppBMI，分娩方式和均价可能会影响母体生理，从而在哺乳期初期影响糖基化。我们的观察性研究是欧洲最大的标准化和纵向（最长4个月）牛奶收集研究，用于评估HMO浓度和基本母体特征。哺乳时间和牛奶组对HMO变异的影响最大。未来的研究需要阐明这些观察结果，并评估对母乳喂养婴儿的生理意义。
更新日期：2019-08-13
中文翻译：
一群健康的欧洲母亲在哺乳期的前四个月中，母性特征对人乳寡糖组成的影响。
母乳中的人乳低聚糖（HMO）组成各不相同，并且在哺乳期间会发生变化。个体间的差异主要由岩藻糖基转移酶（FUT2和FUT3）多态性驱动，导致4个不同的牛奶组。关于孕产妇的生理状况是否会导致HMO变异性知之甚少。我们对20种主要HMO的轨迹进行了表征，并探讨了孕妇孕前体重指数（ppBMI），分娩方式或均价是否会影响牛奶HMO的组成。我们使用来自七个欧洲国家/地区的健康母亲（n = 290）的纵向母乳样本，对HMO组成进行了表征，并采用混合线性模型探索了孕产妇特征与单个HMO的关联。我们观察到了HMO特定的时间轨迹和牛奶群的依赖性。我们观察到基于母体ppBMI，分娩方式和均价的HMO浓度相对较小但存在显着差异。我们的发现表明，HMO组成受酶以及底物可用性的影响呈时间依赖性，并且ppBMI，分娩方式和均价可能会影响母体生理，从而在哺乳期初期影响糖基化。我们的观察性研究是欧洲最大的标准化和纵向（最长4个月）牛奶收集研究，用于评估HMO浓度和基本母体特征。哺乳时间和牛奶组对HMO变异的影响最大。未来的研究需要阐明这些观察结果，并评估对母乳喂养婴儿的生理意义。
京公网安备 11010802027423号