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[3+2]-Cycloaddition of α-Diazocarbonyl Compounds with Arenediazonium Salts Catalyzed by Silver Nitrate Delivers 2,5-Disubstituted Tetrazoles
Synthesis ( IF 2.2 ) Pub Date : 2019-08-12 , DOI: 10.1055/s-0039-1690159
Sergey Chuprun , Dmitry Dar’in , Grigory Kantin , Mikhail Krasavin

Abstract

[3+2]-Cycloaddition of arenediazonium salts with diazo compounds (earlier exemplified only for trimethylsilyldiazomethane and 2,2,2-trifluorodiazoethane) has been developed to include a wide range of readily available α-diazocarbonyl compounds. The resulting 2-aryl-5-acyl-2H-tetrazoles are of high value in medicinal chemistry.

[3+2]-Cycloaddition of arenediazonium salts with diazo compounds (earlier exemplified only for trimethylsilyldiazomethane and 2,2,2-trifluorodiazoethane) has been developed to include a wide range of readily available α-diazocarbonyl compounds. The resulting 2-aryl-5-acyl-2H-tetrazoles are of high value in medicinal chemistry.



中文翻译:

硝酸银催化[3 + 2]-重氮化合物与亚砷鎓盐的环加成反应,得到2,5-二取代的四唑

抽象的

已经开发了芳族重氮鎓盐与重氮化合物的[3 + 2]-环加成反应(先前仅以三甲基甲硅烷基重氮甲烷和2,2,2-三氟重氮乙烷为例),已包括了多种易于获得的α-重氮羰基化合物。所得的2-芳基-5-酰基-2 H-四唑在医学化学中具有很高的价值。

已经开发了芳族重氮鎓盐与重氮化合物的[3 + 2]-环加成反应(先前仅以三甲基甲硅烷基重氮甲烷和2,2,2-三氟重氮乙烷为例),已包括了多种易于获得的α-重氮羰基化合物。所得的2-芳基-5-酰基-2 H-四唑在医学化学中具有很高的价值。

更新日期:2019-08-12
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