Mechanochemistry and organic synthesis: from mystical to practical,Green Chemistry

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Mechanochemistry and organic synthesis: from mystical to practical
Green Chemistry ( IF 9.3 ) Pub Date : 2018-02-27 00:00:00 , DOI: 10.1039/c7gc03797j
J. Andersen _{1,

2,

3,

4} , J. Mack _{1,

2,

3,

4}

Affiliation

Perhaps due in no small part to its historical mystique, mechanochemistry has been shrowded in relative obscurity for quite some time. The successes of mechanochemistry in organic synthesis have often been curtailed by a fundamentally limited mechanistic understanding. Lately, however, the community has made great strides towards understanding the fundamentals, as well as large steps forward regarding industrially significant scale-up via twin-screw extrusion. A variety of recent work has traded in some of mechanochemistry's mystique for simple, straight-forward chemical guidelines. This exchange eases the concerns of a would-be practitioner of mechanochemistry, interested in having another tool in their lab. Simultaneously, pressures on institutions and researchers regarding lab safety, environmental awareness, productivity, and so on, continue to make mechanochemistry particularly attractive. The demand has never been higher for a methodology addressing these pressures, and at the same time the barriers to adopting mechanochemistry have never been lower. That being said, there still remains some mystique guarding the “rules” of mechanochemistry. For those interested in solving these fundamental questions, there remain plenty of high-value targets, and several of these will feature throughout this review.

中文翻译：

机械化学和有机合成：从神秘到实践

也许是由于它的历史神秘性，在相当长的一段时间内，机械化学一直处于相对模糊的状态。机械化学在有机合成中的成功常常被根本上有限的机械理解所限制。但是，最近，该社区在理解基本原理方面取得了长足的进步，并且在通过双螺杆挤出。机械化学的一些奥秘之处以各种简单而直接的化学指导原则为代表，进行了许多近期的研究。这种交流减轻了希望成为机械化学从业者的担忧，他们对在实验室中使用另一种工具感兴趣。同时，机构和研究人员在实验室安全，环境意识，生产率等方面的压力继续使机械化学特别有吸引力。解决这些压力的方法的需求从未如此高，同时采用机械化学的障碍从未如此低。话虽如此，仍然存在一些迷信机械化学的“规则”。对于那些有兴趣解决这些基本问题的人，仍然有很多高价值目标，

更新日期：2018-04-03

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