An Efficient Surface Modification Strategy Improving Endothelialization with Polydopamine Nanoparticles and REDV Peptides for Stent-Grafts,ACS Applied Bio Materials

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An Efficient Surface Modification Strategy Improving Endothelialization with Polydopamine Nanoparticles and REDV Peptides for Stent-Grafts
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2019-08-21 , DOI: 10.1021/acsabm.9b00421
Wen Xue ₁ , Seyedmehdi Hossaini Nasr ₂ , Guoping Guan ₁ , Liheng Gao ₁ , Fan Zhao ₁ , Jing Gao _{1,

3} , Fujun Wang _{1,

3} , Chunqi Qian ₄ , Lu Wang _{1,

3}

Affiliation

Stents or stent-grafts are often functionalized with films to enhance cell/surface interactions and improve endothelialization. However, continuous film coatings by common surface modification tactics may preclude cells from migrating along the thickness direction and may change the physical characteristics of stent-grafts. Here, polydopamine nanoparticles (PDA-NPs) are attached on braided stent-grafts tightly, forming a nanostructure on microfilaments. They also serve as the anchor for bioactive REDV peptide immobilization to promote endothelia cells (ECs) activities. The results show that braided stent-grafts decorated with PDA-NPs and REDV demonstrate an excellent endothelialization performance and hemocompatibility due to the micro/nanostructure formed and REDV affinity to ECs. The physical properties of stent-grafts are also not compromised. A potential surface modification strategy for scaffold applications is illustrated.

中文翻译：

一种有效的表面改性策略，用聚多巴胺纳米颗粒和 REDV 肽改善支架移植物的内皮化

支架或支架移植物通常用薄膜功能化，以增强细胞/表面相互作用并改善内皮化。然而，通过常见的表面改性策略进行的连续薄膜涂层可能会阻止细胞沿厚度方向迁移，并可能改变支架移植物的物理特性。在这里，聚多巴胺纳米粒子 (PDA-NPs) 紧密地附着在编织的支架移植物上，在微丝上形成纳米结构。它们还作为生物活性 REDV 肽固定的锚，以促进内皮细胞 (EC) 的活动。结果表明，由于形成的微/纳米结构和 REDV 对 ECs 的亲和力，装饰有 PDA-NPs 和 REDV 的编织支架移植物表现出优异的内皮化性能和血液相容性。覆膜支架的物理特性也没有受到影响。

更新日期：2019-08-21

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