Spatial coordination in a mutually beneficial bacterial community enhances its antibiotic resistance.,Communications Biology

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Spatial coordination in a mutually beneficial bacterial community enhances its antibiotic resistance.
Communications Biology ( IF 5.2 ) Pub Date : 2019-08-08 , DOI: 10.1038/s42003-019-0533-0
Lingjun Li ₁ , Tian Wu ₂ , Ying Wang ₂ , Min Ran ₂ , Yu Kang ₃ , Qi Ouyang _{1,

2,

4} , Chunxiong Luo _{1,

2}

Affiliation

Microbial communities can survive in complex and variable environments by using different cooperative strategies. However, the behaviors of these mutuality formed communities remain poorly understood, particularly with regard to the characteristics of spatial cooperation. Here, we selected two Escherichia coli strains, designated as the nutrition provider and the antibiotic protector, respectively, for construction of a mutually beneficial bacterial community that could be used to study these behaviors. We found that in addition to the functional mutualism, the two strains also cooperated through their spatial distribution. Under antibiotic pressure, the bacterial distribution changed to yield different spatial distributions, which resulted in community growth advantages beyond functional cooperation. The mutualistic behavior of these two strains suggested that similar communities could also use variations in spatial distribution to improve their survival rates in a natural environment or under the action of antibiotics.

中文翻译：

互利的细菌群落中的空间协调增强了其抗生素耐药性。

微生物群落可以通过使用不同的合作策略在复杂多变的环境中生存。然而，人们对这些相互形成的群落的行为仍然知之甚少，特别是在空间合作的特征方面。在这里，我们选择了两种大肠杆菌菌株，分别指定为营养提供者和抗生素保护者，以构建可用于研究这些行为的互利细菌群落。我们发现，除了功能互利之外，两种菌株还通过空间分布进行合作。在抗生素压力下，细菌分布发生变化，产生不同的空间分布，从而导致群落生长优势超越功能合作。这两种菌株的互惠行为表明，相似的群落也可以利用空间分布的变化来提高它们在自然环境或抗生素作用下的存活率。

更新日期：2019-08-08

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