Talin-Integrin的力导向“机械相互作用组”。,Biochemistry

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Talin-Integrin的力导向“机械相互作用组”。
Biochemistry ( IF 2.9 ) Pub Date : 2019-08-21 , DOI: 10.1021/acs.biochem.9b00442
Soham Chakraborty ₁ , Souradeep Banerjee ₁ , Manasven Raina ₁ , Shubhasis Haldar ₁

Affiliation

从细胞外基质到细胞的机械转导主要受跨膜受体整联蛋白和胞质蛋白塔林的监督。整联蛋白在细胞外侧结合配体，而塔林将整联蛋白受体偶联至肌动蛋白细胞骨架，随后充当“力缓冲液”。塔林和整联蛋白共同形成了一个机械敏感的信号枢纽，可调节关键的细胞过程和途径，包括细胞信号传导和粘着斑复合物的形成，帮助细胞感知其机械环境并相应地传导信号。尽管这两种蛋白串联在一起起作用，但是大多数文献都将它们单独地集中在它们上。在这里，我们根据其在机械转导过程中的作用及其与疾病的联系，对塔林-整联蛋白机械相互作用网络进行了重点综述。这些蛋白质在强力作用下，会驱动许多生物分子相互作用并形成粘附复合物，进而控制许多生理过程，例如细胞迁移。因此，它们总是与几种疾病相关，从白细胞粘附不足到癌症。深入了解它们在这些病理性疾病发生中的作用可能会导致我们建立治疗方法和治疗技术。

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Force-Directed "Mechanointeractome" of Talin-Integrin.

Mechanotransduction from the extracellular matrix into the cell is primarily supervised by a transmembrane receptor, integrin, and a cytosolic protein, talin. Integrin binds ligands on the extracellular side, whereas talin couples integrin receptors to the actin cytoskeleton and later acts as a “force buffer”. Talin and integrin together form a mechanosensitive signaling hub that regulates crucial cellular processes and pathways, including cell signaling and formation of focal adhesion complexes, which help cells to sense their mechano-environment and transduce the signal accordingly. Although both proteins function in tandem, most literature focuses on them individually. Here, we provide a focused review of the talin–integrin mechano-interactome network in light of its role in the process of mechanotransduction and its connection to diseases. While working under force, these proteins drive numerous biomolecular interactions and form adhesion complexes, which in turn control many physiological processes such as cell migration; thus, they are invariably associated with several diseases from leukocyte adhesion deficiency to cancer. Gaining insights into their role in the occurrence of these pathological disorders might lead us to establish treatment methods and therapeutic techniques.

更新日期：2019-08-21

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