Due to the decrease of the drugs side effects in controlled drug delivery systems, today's many research has been focused on designing the new controlled drug delivery systems. The main aim of the present work was the improving of the layered double hydroxide (LDH) properties as a drug delivery system through the encapsulation with carboxymethyl cellulose (CMC). In the first section, 5-fluorouracil (5-Fu) as a colon anticancer drug was loaded in LDH(Zn/Al) (about 87%). The FT-IR, SEM, and XRD analysis were used to probe the successful synthesis of LDH(Zn/Al) and 5-Fu loading in it. In the following, the nanohybrid encapsulated with CMC, through the crosslinking of the LDH(Zn/Al)-5-Fu and CMC mixture with Fe(III) as a physical crosslinker and CMC/LDH(Zn/Al)-5-Fu hydrogel beads were formed. From comparing of the 5-Fu release from the LDH(Zn/Al)-5-Fu and CMC/LDH(Zn/Al)-5-Fu hydrogel beads, it was found that the use of CMC as a capsule induce the controlled and sustained drug release behavior to the system. MTT assay approved the biocompatibility of the CMC/LDH(Zn/Al)-5-Fu hydrogel beads. With considering the swelling, drug loading, drug-releasing, and MTT assay results, the prepared CMC/LDH(Zn/Al)-5-Fu hydrogel beads system could be proposed as a potentially safe oral delivery system for colon cancer therapy.

由于受控药物输送系统中药物副作用的减少，今天的许多研究都集中在设计新的受控药物输送系统上。本工作的主要目的是通过用羧甲基纤维素（CMC）包封来改善层状双氢氧化物（LDH）作为药物递送系统的性能。在第一部分中，将5-氟尿嘧啶（5-Fu）作为结肠癌抗癌药物加载到LDH（Zn / Al）中（约87％）。FT-IR，SEM和XRD分析被用来探测LDH（Zn / Al）的成功合成和其中5-Fu的负载。在下文中，通过LDH（Zn / Al）-5-Fu和CMC混合物与作为物理交联剂的Fe（III）和CMC / LDH（Zn / Al）-5-Fu的CMC混合物的交联，用CMC包裹的纳米杂化物形成水凝胶珠。通过比较LDH（Zn / Al）-5-Fu和CMC / LDH（Zn / Al）-5-Fu水凝胶珠中的5-Fu释放量，发现使用CMC作为胶囊剂可诱导受控和持续的药物释放行为。MTT分析证实了CMC / LDH（Zn / Al）-5-Fu水凝胶珠的生物相容性。考虑到肿胀，载药量，药物释放和MTT分析结果，所制备的CMC / LDH（Zn / Al）-5-Fu水凝胶微珠系统可作为结肠癌治疗的潜在安全口服给药系统。