Synthesis of β3-Amino Esters by Iridium-Catalyzed Asymmetric Allylic Alkylation Reaction,Organic Process Research & Development

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Synthesis of β3-Amino Esters by Iridium-Catalyzed Asymmetric Allylic Alkylation Reaction
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2019-08-07 00:00:00 , DOI: 10.1021/acs.oprd.9b00280
Chao-Guo Cao ₁ , Bin He ₁ , Zhengyan Fu ₁ , Dawen Niu ₁

Affiliation

A method to prepare chiral β³-amino esters from methyl 3-aminopropanoate was described. This method capitalized on a sequence involving an Ir-catalyzed asymmetric allylation of 2-azaallyl anions and a 2-aza-Cope rearrangement. β³-Amino esters containing a versatile alkene group were prepared.

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