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Efficient Production of Cyclopropylamine by a Continuous-Flow Microreaction System
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2019-08-20 , DOI: 10.1021/acs.iecr.9b02438 Jinpei Huang 1 , Yuhao Geng 1 , Yundong Wang 1 , Jianhong Xu 1
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2019-08-20 , DOI: 10.1021/acs.iecr.9b02438 Jinpei Huang 1 , Yuhao Geng 1 , Yundong Wang 1 , Jianhong Xu 1
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Cyclopropylamine (CPA) is an essential intermediate in the preparation of many biologically active substances. The traditional batch method to prepare CPA is facing many problems in the Hofmann rearrangement step, such as low production efficiency, poor stability, and complex process. In this paper, a novel continuous-flow method was developed to prepare CPA with high efficiency. Taking advantages of characteristics of the continuous-flow microreaction system, the simple process with a one-stage reaction was successfully realized instead of the original two-stage reaction in batch reactors. The yield of CPA reached up to 96% in only 4 min residence time at 90 °C. Interestingly, with the higher feed temperature, the reaction concentration in continuous-flow approach can be even higher than that in the batch method.
中文翻译：
连续流微反应系统高效生产环丙胺
环丙胺（CPA）是许多生物活性物质制备中必不可少的中间体。传统的间歇法制备CPA在霍夫曼重排步骤中面临许多问题，例如生产效率低，稳定性差和工艺复杂。本文开发了一种新颖的连续流方法来高效制备CPA。利用连续流微反应系统的特性，成功地实现了具有一步反应的简单过程，而不是间歇式反应器中最初的两步反应。在90°C下仅停留4分钟，CPA的收率就达到了96％。有趣的是，随着进料温度的升高，连续流方法中的反应浓度甚至可以比间歇方法中的更高。
更新日期：2019-08-20
中文翻译：
连续流微反应系统高效生产环丙胺
环丙胺（CPA）是许多生物活性物质制备中必不可少的中间体。传统的间歇法制备CPA在霍夫曼重排步骤中面临许多问题，例如生产效率低，稳定性差和工艺复杂。本文开发了一种新颖的连续流方法来高效制备CPA。利用连续流微反应系统的特性，成功地实现了具有一步反应的简单过程，而不是间歇式反应器中最初的两步反应。在90°C下仅停留4分钟，CPA的收率就达到了96％。有趣的是，随着进料温度的升高，连续流方法中的反应浓度甚至可以比间歇方法中的更高。
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