Department of Pharmaceutical Analysis; The Fourth Military Medical University; 169th Changle west road Xi'an Shaanxi 710032 China
Department of Physics; The Chinese University of Hong Kong; Shatin New Territories Hong Kong
Beijing Computational Science Research Center; No.10 East Xibeiwang Road Haidian District Beijing 100193 China
School of Biomedical Sciences; The Chinese University of Hong Kong; Shatin New Territories Hong Kong
Department of Immunology; The Fourth Military Medical University; 169th Changlewest road Xi'an Shaanxi 710032 China
The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to overcome drug resistance in cancer therapeutics. In article number 1700289, Quan Li and co‐workers demonstrate the feasibility of using self‐decomposable nanoparticle drug carriers as intracellular drug reservoirs that enable delivery of a stable therapeutic concentration, leading to complete reversal of multidrug resistance.
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