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Anisotropic Hybrid Hydrogels with Superior Mechanical Properties Reminiscent of Tendons or Ligaments
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-08-06 , DOI: 10.1002/adfm.201904342
Suji Choi 1 , Youngjin Choi 1 , Jaeyun Kim 1, 2, 3
Affiliation  

Mimicking the hierarchically anisotropic structure and excellent mechanical properties of natural tissues, such as tendons and ligaments, using biomaterials is challenging. Despite recent achievements with anisotropic hydrogels, limitations remain because of difficulties in achieving both structural and mechanical characteristics simultaneously. A simple approach for fabricating hybrid hydrogels with a hierarchically anisotropic structure and superior mechanical properties that are reminiscent of tendons or ligaments is proposed. Alginate–polyacrylamide double‐network (DN) hydrogels incorporated with high aspect ratio mesoporous silica microparticles are stretched and fixed via subsequent drying and ionic crosslinking to achieve multiscale structures composed of an anisotropically aligned polymer network embedded with aligned microparticles. The mechanical properties of hydrogels can be further controlled by the degree of stretching, quantities, and functional groups of inorganic microparticles, and types of crosslinking cations. The subsequent reswelling results in a high water content (>80%) similar to that of natural tendons while high strength, modulus, and toughness are maintained. The optimized anisotropic hybrid hydrogel exhibits a tensile modulus of 7.2 MPa, strength of 1.3 MPa, and toughness of 1.4 MJ m−3 even in the swollen state, which is 451‐, 27‐, and 2.2 times higher than that observed in the non‐swollen tough DN hydrogel. This study suggests a new strategy for fabricating anisotropic hydrogels with superior mechanical properties to develop new biomaterials for artificial tendons or ligaments.

中文翻译:

具有优异的机械性能,使人联想到肌腱或韧带的各向异性杂化水凝胶

使用生物材料模仿自然组织(如腱和韧带)的分层各向异性结构和出色的机械性能具有挑战性。尽管各向异性水凝胶最近取得了成就,但由于同时获得结构和机械特性方面的困难,仍然存在局限性。提出了一种简单的方法来制造具有层次各向异性结构和优异的机械性能的混合水凝胶,这种结构让人联想到腱或韧带。通过随后的干燥和离子交联拉伸和固定高纵横比介孔二氧化硅微粒的藻酸盐-聚丙烯酰胺双网络(DN)水凝胶,以实现由各向异性排列的聚合物网络嵌入排列的微粒组成的多尺度结构。可以通过拉伸程度,无机微粒的数量和官能团以及交联阳离子的类型来进一步控制水凝胶的机械性能。随后的溶胀导致与天然肌腱相似的高含水量(> 80%),同时保持了高强度,模量和韧性。优化的各向异性杂化水凝胶的拉伸模量为7.2 MPa,强度为1.3 MPa,韧性为1.4 MJ m-3即使在溶胀状态下,也比在非溶胀坚韧的DN水凝胶中观察到的高451-,27-和2.2倍。这项研究提出了一种制备具有优异机械性能的各向异性水凝胶的新策略,以开发用于人造肌腱或韧带的新型生物材料。
更新日期:2019-08-06
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