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Antibacterial, Antibiofilm, Antiquorum Sensing, Antimotility, and Antioxidant Activities of Green Fabricated Ag, Cu, TiO2, ZnO, and Fe3O4 NPs via Protoparmeliopsis muralis Lichen Aqueous Extract against Multi-Drug-Resistant Bacteria
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2019-08-05 00:00:00 , DOI: 10.1021/acsbiomaterials.9b00274 Mehran Alavi , Naser Karimi , Tahereh Valadbeigi 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2019-08-05 00:00:00 , DOI: 10.1021/acsbiomaterials.9b00274 Mehran Alavi , Naser Karimi , Tahereh Valadbeigi 1
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Consideration of lichen organisms as the ecofriendly source of metal nanoparticles (MNPs) and metal oxide NPs (MONPs) synthesis is seldom. In this study, Ag and Cu MNPs as well as TiO2, ZnO, and Fe3O4 MONPs were green synthesized by Protoparmeliopsis muralis lichen aqueous extract. First, physicochemical characterization by UV–vis spectroscopy, XRD, FT-IR, FESEM, and TEM techniques demonstrated the presence possibility of secondary metabolites around formed MNPs/MONPs with different diameters and shapes (spherical, triangular, polyhedral, and cubic). The antibacterial, antibiofilm, antiquorum sensing, and antioxidant abilities of these MNPs/MONPs against multi drug resistant (MDR) bacterium (Staphylococcus aureus ATCC 43300) and reference bacteria (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) were then evaluated by in vitro tests. Results of disc diffusion and MIC/MBC assays of Ag NPs as an effective antibacterial agent illustrated a higher sensitivity of the P. aeruginosa pathogen than E. coli and S. aureus. In next steps, a significant reduction was observed in the biofilm formation of each bacterium and pyocyanin synthesis by P. aeruginosa under Ag NPs. This investigation presents novel clean production of five MNPs/MONPs with prominent advantages of being ecofriendly and cost-effective and having antipathogen properties.
中文翻译：
绿色的Ag，Cu，TiO 2，ZnO和Fe 3 O 4 NPs通过原托壁op虫地衣水提取物对多药耐药细菌的抗菌，生物膜，抗群体感，抗运动性和抗氧化活性
很少考虑将地衣生物作为金属纳米颗粒（MNP）和金属氧化物NP（MONP）合成的生态友好来源。在这项研究中，Ag和Cu MNPs和TiO 2，ZnO和Fe 3 O 4 MONPs是通过Protoparmeliopsis muralis地衣水提取物绿色合成的。首先，通过紫外-可见光谱，XRD，FT-IR，FESEM和TEM技术进行的理化表征表明，形成的MNPs / MONPs具有不同的直径和形状（球形，三角形，多面体和立方），可能存在次级代谢产物。这些MNP / MONP对多药耐药（MDR）细菌（金黄色葡萄球菌）的抗菌，生物膜，抗群体感应和抗氧化能力然后通过体外测试评估参考细菌（大肠杆菌ATCC 25922和铜绿假单胞菌ATCC 27853）。碟片扩散和Ag NPs作为有效抗菌剂的MIC / MBC分析结果表明，铜绿假单胞菌病原菌的敏感性比大肠杆菌和金黄色葡萄球菌高。在接下来的步骤中，在NP下铜绿假单胞菌观察到每种细菌的生物膜形成和绿脓素合成的显着减少。这项研究提出了五种MNPs / MONPs的新型清洁生产方法，其显着优势是生态友好，成本效益高并且具有抗病原特性。
更新日期：2019-08-05
中文翻译：
绿色的Ag，Cu，TiO 2，ZnO和Fe 3 O 4 NPs通过原托壁op虫地衣水提取物对多药耐药细菌的抗菌，生物膜，抗群体感，抗运动性和抗氧化活性
很少考虑将地衣生物作为金属纳米颗粒（MNP）和金属氧化物NP（MONP）合成的生态友好来源。在这项研究中，Ag和Cu MNPs和TiO 2，ZnO和Fe 3 O 4 MONPs是通过Protoparmeliopsis muralis地衣水提取物绿色合成的。首先，通过紫外-可见光谱，XRD，FT-IR，FESEM和TEM技术进行的理化表征表明，形成的MNPs / MONPs具有不同的直径和形状（球形，三角形，多面体和立方），可能存在次级代谢产物。这些MNP / MONP对多药耐药（MDR）细菌（金黄色葡萄球菌）的抗菌，生物膜，抗群体感应和抗氧化能力然后通过体外测试评估参考细菌（大肠杆菌ATCC 25922和铜绿假单胞菌ATCC 27853）。碟片扩散和Ag NPs作为有效抗菌剂的MIC / MBC分析结果表明，铜绿假单胞菌病原菌的敏感性比大肠杆菌和金黄色葡萄球菌高。在接下来的步骤中，在NP下铜绿假单胞菌观察到每种细菌的生物膜形成和绿脓素合成的显着减少。这项研究提出了五种MNPs / MONPs的新型清洁生产方法，其显着优势是生态友好，成本效益高并且具有抗病原特性。
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