Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation.,Nature Biomedical Engineering

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Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation.
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2019-08-05 , DOI: 10.1038/s41551-019-0432-1
Raza Qazi _{1,

2} , Adrian M Gomez ₃ , Daniel C Castro _{3,

4} , Zhanan Zou ₅ , Joo Yong Sim ₆ , Yanyu Xiong ₂ , Jonas Abdo ₂ , Choong Yeon Kim ₁ , Avery Anderson ₂ , Frederik Lohner ₂ , Sang-Hyuk Byun ₁ , Byung Chul Lee ₇ , Kyung-In Jang ₈ , Jianliang Xiao ₅ , Michael R Bruchas _{3,

4,

9,

10,

11,

12,

13,

14} , Jae-Woong Jeong _{1,

2}

Affiliation

School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Department of Electrical, Computer, and Energy Engineering, University of Colorado, Boulder, CO, USA.
Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO, USA.
Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Department of Mechanical Engineering, University of Colorado, Boulder, CO, USA.
Welfare & Medical ICT Research Department, Electronics and Telecommunications Research Institute, Daejeon, Republic of Korea.
Center for BioMicrosystems, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Department of Pharmacology, University of Washington, Seattle, WA, USA.
Department of Bioengineering, University of Washington, Seattle, WA, USA.

Both in vivo neuropharmacology and optogenetic stimulation can be used to decode neural circuitry, and can provide therapeutic strategies for brain disorders. However, current neuronal interfaces hinder long-term studies in awake and freely behaving animals, as they are limited in their ability to provide simultaneous and prolonged delivery of multiple drugs, are often bulky and lack multifunctionality, and employ custom control systems with insufficiently versatile selectivity for output mode, animal selection and target brain circuits. Here, we describe smartphone-controlled, minimally invasive, soft optofluidic probes with replaceable plug-like drug cartridges for chronic in vivo pharmacology and optogenetics with selective manipulation of brain circuits. We demonstrate the use of the probes for the control of the locomotor activity of mice for over four weeks via programmable wireless drug delivery and photostimulation. Owing to their ability to deliver both drugs and photopharmacology into the brain repeatedly over long time periods, the probes may contribute to uncovering the basis of neuropsychiatric diseases.

中文翻译：

无线光流体脑探头，用于慢性神经药理学和光刺激。

体内神经药理学和光遗传学刺激均可用于解码神经回路，并可为脑部疾病提供治疗策略。然而，当前的神经元接口阻碍了对处于清醒状态和自由行为状态的动物的长期研究，因为它们提供多种药物同时且长时间递送的能力有限，通常体积庞大且缺乏多功能性，并且采用通用性不足的定制控制系统用于输出模式，动物选择和目标大脑电路。在这里，我们描述了智能手机控制的，微创的，柔软的光流体探针，带有可替换的塞子状药盒，用于慢性体内药理学和光遗传学，具有选择性操纵大脑回路的能力。我们展示了通过可编程的无线药物递送和光刺激，在超过四个星期的时间内，使用该探针控制小鼠的自发活动。由于它们能够在很长一段时间内将药物和光药理学重复地输送到大脑中，因此这些探针可能有助于揭示神经精神疾病的基础。

更新日期：2019-08-05

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