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Ring-Opening Reactions of Donor–Acceptor Cyclobutanes with Electron-Rich Arenes, Thiols, and Selenols
Organic Letters ( IF 4.9 ) Pub Date : 2019-08-05 00:00:00 , DOI: 10.1021/acs.orglett.9b02197
Alexander Kreft , Stephanie Ehlers , Peter G. Jones , Daniel B. Werz

Donor–acceptor (D–A) cyclobutanes with two geminal ester groups as acceptors are reacted with electron-rich arenes as nucleophiles to afford ring-opened products. AlCl3 mediates this Friedel–Crafts-type reaction. A variety of donors and electron-rich arenes are used. Nucleophilic thiols and selenols also trigger this ring-opening reaction. Furthermore, a comparison of various physical parameters has been carried out for several D–A cyclobutanes.

中文翻译:

供体-受体环戊二烯与电子富集的芳烃,硫醇和硒醇的开环反应

具有两个双酯基团作为受体的供体-受体(D-A)环丁烷与作为亲核试剂的富电子芳烃反应,提供开环产物。AlCl 3介导了这种Friedel-Crafts型反应。使用了多种供体和富含电子的芳烃。亲核硫醇和硒醇也会触发这种开环反应。此外,已经对几种D–A环丁烷进行了各种物理参数的比较。
更新日期:2019-08-05
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