Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.,PLOS Genetics

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Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
PLOS Genetics ( IF 4.0 ) Pub Date : 2019-08-01 , DOI: 10.1371/journal.pgen.1008236
Amanda Vlahos ₁ , Toby Mansell _{1,

2} , Richard Saffery _{1,

2} , Boris Novakovic _{1,

2}

Affiliation

The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development. The unique epigenetic profile of the human placenta likely reflects its early developmental separation from the fetus proper and its role in mediating maternal-fetal exchange that leaves it open to a range of exogenous exposures in the maternal circulation. In this review, we cover recent advances in DNA methylation in the context of placental function and development, as well as the interaction between the pregnancy and the environment.

中文翻译：

人胎盘甲基化与不良胎盘健康，环境暴露和妊娠结局的相互作用。

胎盘是母体和胎儿循环之间的界面，整合母体和胎儿信号以选择性地调节营养，气体和废物交换以及分泌激素。反过来，胎盘有助于创造子宫内环境并控制胎儿的生长发育。人类胎盘独特的表观遗传学特征可能反映了其与胎儿固有的早期发育分离，以及其在介导母胎交换中的作用，使它容易暴露于母体循环中的一系列外源性暴露。在这篇综述中，我们涵盖了胎盘功能和发育以及妊娠与环境之间相互作用方面DNA甲基化的最新进展。

更新日期：2019-08-31

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