Chitosan-mediated green synthesis and folic-acid modification of CuS quantum dots for photoacoustic imaging guided photothermal therapy of tumor,Journal of Colloid and Interface Science

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Chitosan-mediated green synthesis and folic-acid modification of CuS quantum dots for photoacoustic imaging guided photothermal therapy of tumor
Journal of Colloid and Interface Science ( IF 9.4 ) Pub Date : 2019-08-02 , DOI: 10.1016/j.jcis.2019.08.001
Wanjian Yu ₁ , Nuo Yu ₂ , Zhaojie Wang ₂ , Xuan Li ₂ , Cen Song ₂ , Ruiqi Jiang ₂ , Peng Geng ₂ , Maoquan Li ₃ , Shiwu Yin ₄ , Zhigang Chen ₁

Affiliation

CuS nanomaterials capped with artificial organic-molecules or polymers have been well demonstrated as efficient photothermal nanoagents for the therapy of tumor, but their biocompatibility and target ability should be improved. To address these problems, we have used chitosan (CS) as the biomacromolecule model and surface ligands to prepare CuS quantum dots (QDs) via a simple co-precipitation method. CuS-CS QDs are then conjugated with folic acid (FA). The resulting CuS-CS-FA QDs are composed of hexagonal phase nanodots with sizes of about 4 nm. FA modification process has no apparent influence on the size, phase and composition of the QDs. Furthermore, the zeta potential and infrared spectroscopy confirm the efficient conjugation of FA. CuS-CS-FA QDs exhibit strong near-infrared photoabsorption and high photothermal efficiency (47.0%). As a result of the presence of CS ligand and FA modification, CuS-CS-FA QDs have good biocompatibility and relatively high cellular uptake efficacy. When CuS-CS-FA QD dispersion is injected intravenously into the tumor-bearing mice, the photoacoustic imaging reveals that CuS-CS-FA QD can be efficiently targeted and accumulated in the tumor and reach the peak dose at 60 min. The irradiation of 1064-nm laser (1.0 W cm−2, 10 min) results in the efficient inhibition of tumor growth, without treatment-induced toxicity. Therefore, CuS-CS-FA QDs have great potential to become biocompatible multifunctional nanoagents for imaging guided therapy of tumor.

中文翻译：

壳聚糖介导的 CuS 量子点的绿色合成和叶酸修饰用于光声成像引导的肿瘤光热治疗

用人工有机分子或聚合物覆盖的 CuS 纳米材料已被证明是治疗肿瘤的高效光热纳米剂，但其生物相容性和靶向能力有待提高。为了解决这些问题，我们使用壳聚糖（CS）作为生物大分子模型和表面配体，通过简单的共沉淀方法制备 CuS 量子点（QD）。然后将 CuS-CS QD 与叶酸（FA）偶联。所得的 CuS-CS-FA QD 由尺寸约为 4 nm 的六方相纳米点组成。FA 修饰过程对 QD 的大小、相和组成没有明显影响。此外，zeta 电位和红外光谱证实了 FA 的有效共轭。CuS-CS-FA QD 表现出较强的近红外光吸收和高光热效率（47.0%）。由于 CS 配体和 FA 修饰的存在，CuS-CS-FA QD 具有良好的生物相容性和相对较高的细胞摄取效率。当 CuS-CS-FA QD 分散体静脉注射到荷瘤小鼠体内时，光声成像显示 CuS-CS-FA QD 可以有效地靶向并在肿瘤中积累，并在 60 min 时达到峰值剂量。1064 nm 激光（1.0 W cm-2， 10 min）的照射可有效抑制肿瘤生长，而不会产生治疗诱导的毒性。因此，CuS-CS-FA QD 具有成为用于肿瘤成像引导治疗的生物相容性多功能纳米制剂的巨大潜力。

更新日期：2019-08-02

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