No metal, no cry! Macrocyclic polyamines (MPAs) are important chelating agents for cations, anions, and neutral molecules; cyclen and DOTA are well‐known contrast agents for MR or PET/SPECT imaging. Their unique properties also make them attractive multivalent molecular platforms for applications far beyond conventional metal chelation. Their use in materials chemistry, medicinal chemistry, and chemical biology is discussed.

中文翻译：

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除金属螯合外，大环多胺的应用范围

没有金属，没有哭泣！大环多胺（MPA）是阳离子，阴离子和中性分子的重要螯合剂。cyclen和DOTA是用于MR或PET / SPECT成像的众所周知的造影剂。它们的独特性能也使它们成为有吸引力的多价分子平台，其应用范围远远超出了常规的金属螯合。讨论了它们在材料化学，药物化学和化学生物学中的用途。