Copper‐Promoted Tandem Three‐Component Access to Quinazolin‐4(H)‐imines and Benzimidazo[1,2‐c]quinazolines,Advanced Synthesis & Catalysis

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Copper‐Promoted Tandem Three‐Component Access to Quinazolin‐4(H)‐imines and Benzimidazo[1,2‐c]quinazolines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2019-08-13 , DOI: 10.1002/adsc.201900658
Romain Rodrigues ₁ , Lam Quang Tran ₁ , Benjamin Darses ₂ , Philippe Dauban ₁ , Luc Neuville ₁

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A copper‐catalyzed three‐component assembly of cyanamides, 2‐cyanoarylboronic acids and amines has been developed, providing functionalized quinazolin‐4(H)‐imines. Subsequent access to benzimidazo[1,2‐c]quinazolines is achieved building again on copper‐catalysis. One pot hydrolysis of quinazolin‐4(H)‐imines to quinazolin‐4(3H)‐ones is also described. Guanidine formation, cyclization and intramolecular C−H bond amination are key features of the process fully mediated by copper.

中文翻译：

铜促进的串联三组分访问喹唑啉-4（H）-亚胺和苯并咪唑并[1,2-c]喹唑啉

已经开发出了铜催化的氰胺，2-氰基芳基硼酸和胺的三组分组装体，提供了功能化的喹唑啉-4（H）-亚胺。随后在铜催化下再次获得苯并咪唑[1,2- c ]喹唑啉。还描述了一锅水解喹唑啉-4（H）-亚胺水解为喹唑啉-4（3 H）-一。胍的形成，环化和分子内CH键胺化是完全由铜介导的过程的关键特征。

更新日期：2019-08-13

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